There is an overview of the current literature data, which reflects the key aspects of the etiology and pathogenesis of psoriasis. A genetically determined, multifactorial nature of the dermatosis was displayed. There were summarized numerous domestic and foreign data on immunological (cellular, humoral, mediator, extravasation, angiogenesis) and non-immune mechanisms of genesis of psoriasis.
Nikolashina О.Е., Bakulev A.L. On the relationship between innate and adaptive immunity in psoriasis // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 421-423

Objective: to improve treatment of patients with limited sclerodermia (LSD) by increasing efficiency and reducing the time of their treatment. Material and methods. The examination and treatment of 52 patients with circumscribed scleroderma were conducted. Two groups of these patients were formed with method of adaptive randomization. In the control group complex treatment was underwent according to the standards in this nosology. In the general group the patients additionally received antioxidant therapy. The course of treatment was 21 days in both groups. Results. Treatment results were evaluated in accordance with the dynamics of cutaneous pathological process and cytokine profile. In the course of treatment positive clinical dynamics in patients of the study group went faster and was accompanied by a more pronounced reduction in inflammatory activity in the blood serum. Conclusion. The results suggest that antioxidant therapy improves the efficiency and reduces the treatment time of patients with circumscribed sclerodermia.
Tlish M.M., Sorokina N.V. Cytokine markers of the efficiency of correction of oxidative stress in patients with limited sclerodermia // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 410-414

Objective: to compare the clinical and laboratory evaluation of the efficacy of leflunomide and narrow-band medium wave UV therapy in patients with psoriasis. Material and methods. 60 patients with psoriasis. The patients were divided into 2 groups depending on the treatment. Patients of group 1 (30 patients) administered narrowband medium wave UV therapy — 20 procedures. Group 2 patients (30 persons) received leflunomide in combination with narrow-band medium wave UV-therapy. To evaluate the effectiveness of therapy studied cytokine profile. Results. Patients treated with leflunomide combined with phototherapy, marked a significant shift of the studied parameters and clearer resolution of lesions on the skin. Conclusion. The use of leflunomide in patients with psoriasis in combination with narrow-band medium wave UV therapy promotes a more definite resolution of psoriatic lesions on the skin and a significant improvement in quality of life, as well as the normalization of peripheral blood cytokine profile.
Nikolashina О.Е. Comparative clinical laboratory evaluation of leflunomide and narrow-band medium wave ultraviolet therapy for psoriasis // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 389-392

Purpose: to establish the diagnostic value of the immune cells composition and cytokine activity of the cells in wound discharge from patients with acute odontogenic inflammatory diseases of maxillofacial region. Materials and methods. A total of 31 patients with acute odontogenic inflammatory diseases of maxillofacial region were examined. The number of immune cells and pro-inflammatory cytokines content (IL1(3, MCP1, IL6, IL8, TNFa) in the wound discharge were determined. Results. It has been established that depending on the severity of the inflammatory process in maxillofacial region the immune cells composition and levels of pro-inflammatory cytokines are changing. Conclusion. Determination of the immune cells composition and level of cytokines in the wound discharge can be used for estimation of the character and severity of acute odontogenic inflammatory processes in the maxillofacial region.
Lepilin A.V., Zakharova N.B., Fedotenkova D.A., Tereshkina N.E. The value of composition and cytokine activity of wound discharge cells in patients with acute odontogenic inflammatory diseases of the maxillofacial region // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 2, 2015, pp. 173-177

The aim: to prove the necessity of professional oral hygiene before the fixation of permanent orthodontic equipment in individuals with dental and facial anomalies based on the study of biomarkers of gingival fluid. Materials and Methods: Clinical, cytological examination and gingival fluid test on cytokine levels in 80 patients. Results: In patients with dentofacial anomalies observed decline in hygiene index, and increase the content of gingival fluid neutrophils and degenerative epithelial cells. It is accompanied by an increase in the concentration of the main group of pro-inflammatory and osteogenic cytokines, growth factors. Conclusion: Preliminary conducting professional oral hygiene to orthodontic treatment in patients with dentofacial anomalies leads to the conservation values of satisfactory hygienic indices of the mouth. In this case, the increase in the content of gingival fluid neutrophils and degenerative epithelial cells, with increased concentrations of the main group of pro-inflammatory and osteogenic cytokines has been defined insignificant.
Zakharova N.B., Lepilin A.V., Vorobjev D.V., Erokina N.L., Bakhteeva G.R. The use of professional oral hygiene in orthodontic treatment on the results of studies of gingival fluid biomarkers // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 2, 2015, pp. 168-173

Purpose: To establish diagnostic value of the increased content of pro- and anti-inflammatory cytokines (IL-8, MCP-1, RAIL) in gingival fluid at patients with a chronic periodontal disease. Material and Methods: 60 patients with inflammatory periodontal diseases were surveyed. The concentration of the studied cytokines in gingival fluid has been defined. Results: At a periodontal disease the increased level of pro- and anti-inflammatory cytokines in gingival fluid has been noted. Conclusion: Definition of the MCP-1 and IL-8 levels in gingival fluid can be used as a criterion of the prognosis of the severity of inflammatory and destructive processes in the periodontal tissues.
Ostrovskaya L.Yu., Zakharova N.B., Mogila А.Р., Katkhanova L.S., Akulova E.V., Popykhova E.B. Cytokines balance change in gingival fluid at periodontal diseases and its value for the prognosis of regeneration disturbances in periodontal tissues // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 3, 2014, pp. 435-440

In experiments in non-inbred rats, it has been established that chronic intoxication of ethanol (30 days, total dose – 6.0 LD50) essentially reduces concentration of cytokines IFNγ, IL-2, IL-4, IL-10 in blood, increases concentration of IL-6, reduces an interrelation IFNγ/IL-4 in comparison with the control, suppresses of immune responses, which displays the greater lesion of Th1-cells in comparison with Th2-lymphosytes.
Andrey A. Svistunov, Pavel F. Zabrodskii, V.G. Lim and V.F.Grichin The change in function of Th1 and Th2-lymphocytes and cytokine profile at chronic intoxication of ethanol // Russian Open Medical Journal, Vol. 1, Issue 2, 2012, pp. 202-0

Aim: to evaluate the correlations between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgery. Material and methods. The study has been conducted on 53 patients, who were undergone to pancreaticoduodenal resection with lymphadenectomy. Concentrations of interleukin-4 (IL-4) and interleukin-8 (IL-8) in blood serum were studied. Results. The concentrations of IL-8 were higher in patients with complications compared to those without complications. No statistically significant differences in the concentrations of IL-4 were revealed between the studied groups of patients. Conclusion. Concentrations of pro-and anti-inflammatory cytokines can be used to assess the risk of postoperative complications.
Korsakov I.N., Voskanyan S.E., Naydenov E.V., Timashkov D.A., Chervov A.Yu., Volkov A.A., Bolshakov M.S. Correlation between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgical trauma // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 954-957

The purpose of the research was detection of markers of systemic inflammatory response syndrome together with levels of markers of gram-negative endotoxinemia in HIV-patients for evaluation of role of endotoxin in immune system hyperactivation and progression of disease. Material and methods. Evaluation of levels of endotoxin, sCD14, interleu-kin 1(3, TNF-a and C-reactive protein was done in 232 HIV-positive patients. LAL-test, ELISA and biochemical tests were used. Results. The statistically significant increase of levels of all markers of systemic inflammatory response which were investigated was detected in the group of HIV-positive patients, comparing to group of healthy individuals. Direct correlation of sCD14 level with most of markers of systemic inflammatory response was found. Increased level of sCD14 was associated with more prominent clinical and laboratory signs of immunosupression. Conclusion. These results confirm a role of endotoxin which is a marker of microbial translocation and highly active biological substance in pathogenesis of immune system hyperactivation and progression of HIV-infection.
Khasanova G.K., Bikkinina О.I., Anokhin V.A. Microbial translocation and systemic inflammatory response in HIV-infection // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 508-512

Molecular markers of destruction of periodontal tissue and alveolar bone belong to the mediators, participating in maintenance of chronic inflammatory process in the clinical attachment. Purpose: To reveal changes of cytokine profile of gingival fluid and proliferative activity of cells of gum at patients with inflammatory periodontal diseases. Material and methods. Immunohistochemical research of biopsy gum material of 70 patients with periodontal disease with monoclonal antibodies: Ki-67 (marker of proliferative activity of cells), Bcl-2 (apoptosis marker); method of the solid-phase immunofermental analysis for level definition interleukin -6, 10, 12, 18 in gingival fluid (about — and anti-inflammatory markers). Results. It is shown that level definition of cytokines in gingival fluid allows to monitor the activity of the inflammatory process in the periodontal tissues, and the morphometric analysis of periodontal cells reflects degree of its weight. Conclusion. The use of molecular markers in inspection of patients with periodontal disease is the informative method, allowing to predict development and course of chronic periodontal disease.
Ostrovskaya L.U., Beybulatov G.D., Khanina A.I., Mogila А.Р., Katkhanova L.S. Modern immunomorphological aspects of diagnostics of periodontal diseases // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 453-456