Pathogenesis of oral hygiene, smoking, gestosis, immunosuppression and cytokine disbalance affect inflammatory periodontal diseases in pregnant women. The research goal is to study clinical and immunological features of parodentium and cytokine profile in oral cavity of pregnant women. Material and methods: The condition of parodentium tissues was studied at 240 women with physiological pregnancy and 360 with pregnancy complicadet by gestosis. Re-sults: Freguency and character of inflammatory periodontal diseases in pregnancy were defined. Immune and cytokine disbalance contributed greatly to pathogenesis of inflammatory periodontal diseases at pregnant women. Conclusion: Violations of immune homeostasis at the pregnancy, complicated gestosis, authentically are more expressed that contributes to the development of gingivitis and periodontal disease. The imbalance of cytokines can serve in oral liquid as additional diagnostic and predictive marker of severity of a course of inflammatory periodontal disease.
Dubrovskaya M.V., Eremin O.V., Savina Е.А., Ivashchenko Y.Y., Minasyn A.M. Risk factors of development of inflammatory diseases of parodentium in pregnant women // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 383-386

Aim. To study the clinical anti-inflammatory effect of gel form 8% ascorbate chitozan in treatment of inflammatory periodontal disease. Material and methods. The study included 30 patients: 10 patients with chronic catarrhal gingivitis, 10 patients with chronic generalized periodontitis mild and 10 moderate. Criteria for inclusion of patients in the study: age between 18 and 45 years old, reliable diagnosis, informed consent of the patient. Case history of the disease duration from one to five years. The state of periodontal tissue was evaluated clinically and radiographically by intraoral radiography. According to treatment methods patients were divided into groups: group 1 underwent traditional treatment, group 2 was treated with the use of applications of 8% of ascorbate chitosan on the area of papillae and marginal gingiva with the capture of 1-2 cm of the mucous membrane of the alveolar process. The duration of treatment was 15 minutes daily for 10 days. Results. The patterns suggest that the therapeutic effect of ascorbate chitazan caused prolonged sanation of periodontal pockets due to the antibacterial activity of chitazan. Conclusion. The data show that regeneration in patients who have a combined treatment included ascorbate chitosan has been more rapid and complete than similar processes in periodontal patients treated in a traditional way.
Bulkina N.V., Vedyaeva А.P., Tokmakova E.V., Popkova. O.V. Experience of application of ascorbate chitosan in the treatment of periodontal disease // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 372-375

Below in work is shown the usage of Kuriozin (Liquid) in several spheres of practical medicine: Gastro - enterology, Gynecology, Neonatology, Dermatology, Surgery. Also in Maxillo - facial surgery. F irst time is shown medicament’s usage in complex treatment of parod ontal diseases.
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A comparison of the effectiveness of hygiene containing Triklogard and plant extracts in patients with a bracket system. Preference is not revealed. A modification of the index of oral hygiene for patients with braces
Usachev V.V., Juk А.О., Suyetenkov D.Ye., Zakharov A.V. Comparative Efficacy of Oral Hygiene, a Complex Containing Triklogard and Herbal Extracts you have Patients on the Orthodontic Treatment with Braket-system // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 334-336

As a result of the conducted research results of an estimation of efficiency of application of the general eradication are presented therapy and local therapy at sick of inflammatory periodontal diseases against a chronic gastritis. Authors notice a positive effect at application as pathogenetic therapy of balm for gums of "Asepta" that normalisation of level of hygiene of the oral cavity, proof remission of periodontal diseases against a pathology of a gastroenteric path allows to achieve
Osipova J.L, Bulkina N.V. Estimation of efficiency eradication therapies at sick of inflammatory periodontal diseases against a chronic Helicobacter pylori gastritis // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 282-284

The research goal is to study clinical and immunological features of parodentium and cytokine profile in oral cavity of pregnant women. The condition of parodentium tissues was studied at 200 women with physiological pregnancy and 300 women with pregnancy complicated by gestosis. According to the results of examination 50 women with gestosis and 50 women with physiological pregnancy had inflammatory periodontal diseases. Phenotyping of lymphocytes by immunofluorescence method, investigation of necrosis containing factor of tumour-a, interleukin-8, interleukin-4 and transforming growth factor beta-1 in oral cavity by immunofermental analysis were performed. Frequency and character of inflammatory periodontal diseases at pregnancy were defined. Correlation of gingivitis and periodontitis at pregnancy with extragenital pathology was demonstrated. Immune and cytokine disbalance contributed greatly to pathogenesis of inflammatory periodontal diseases at pregnant women. Thus pathogenesis of oral hygiene, smoking, gestosis, immunosuppression and cytokine disbalance affects inflammatory periodontal diseases at pregnant women
A.V. Lepilin, M.V. Dubrovskaya Immunological disorders in formation of periodontal diseases at pregnant women // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 2, 2010, pp. 392-396

The goal of this article is to present review of literature data concerning the problem of combined periodontal lesions and chronic diseases of digestive apparatus from clinical and laboratory-instrumental view point. Gastrointestinal diseases are frequently accompanied by pathologic changes of periodontium. The leading part of such syntropy is disturbance of a number of regulative mechanisms: immune and endocrine disbalance; microcirculatory and neurohumoral regulation; psychosomatic relations; changes in metabolism of connective tissues; mineral metabolism; vitamin deficit. Pathology of digestive system promotes oral microflora negative influence on periodontium, gingivitis and periodontitis development by means of decreasing nonspecific resistance of organism. Pathology of gastrointestinal tract is the risk factor for development and unfavorable clinical course of chronic inflammatory periodontal diseases
O.V. Eremin, A.V. Lepilin, I.V. Kozlova, D.V. Kargin Comorbidity Of Periodontal And Gastrointestinal Diseases // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 393-398

The comparative study of dental status, quality of individual oral hygiene realization and level of dental treatment rendering for students of stomatological faculty from Saratov and for students having no relation to dentistry from Saratov region has been carried out.
V.V. Masumova, N.V. Bulkina, E.A. Savina, A.P. Glybochko STUDY OF DENTAL STATUS, QUALITIES OF INDIVIDUAL ORAL HYGIENE AND LEVEL OF DENTAL TREATMENT IN STUDENTS FROM SARATOV AND SARATOV REGION // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 1, 2009, pp. 90-92

The research purpose is focused on studying the role of protein С system in coagulation component disturbance of hemostasis and fibrinolysis system in patients with different forms of gingivitis. The decrease of protein С and antithrombin inactivity, the decrease ofplasminogen reserve in blood, thrombin time shortening and the resistance of factor Va Via to protein Care watched in patients with different forms of gingivitis. The most marked changes in protein С system may be observed in exacerbation phase of acute and chronic ulcerative generalized gingivitis and chronic catarrhal generalized gingivitis. The reduction of indices of protein С system doesn’t occur in remission phase except in patients with chronic catarrhal ulcera five generalized gingivitis
V.F. Kirichuk, T.V. Simonyan PROTEIN C ROLE IN MICROCIRCULATION DISTURBANCE IN PATIENTS WITH GINGIVITIS // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 2, 2008, pp. 61-63