Molecular markers of destruction of periodontal tissue and alveolar bone belong to the mediators, participating in maintenance of chronic inflammatory process in the clinical attachment. Purpose: To reveal changes of cytokine profile of gingival fluid and proliferative activity of cells of gum at patients with inflammatory periodontal diseases. Material and methods. Immunohistochemical research of biopsy gum material of 70 patients with periodontal disease with monoclonal antibodies: Ki-67 (marker of proliferative activity of cells), Bcl-2 (apoptosis marker); method of the solid-phase immunofermental analysis for level definition interleukin -6, 10, 12, 18 in gingival fluid (about — and anti-inflammatory markers). Results. It is shown that level definition of cytokines in gingival fluid allows to monitor the activity of the inflammatory process in the periodontal tissues, and the morphometric analysis of periodontal cells reflects degree of its weight. Conclusion. The use of molecular markers in inspection of patients with periodontal disease is the informative method, allowing to predict development and course of chronic periodontal disease.
Ostrovskaya L.U., Beybulatov G.D., Khanina A.I., Mogila А.Р., Katkhanova L.S. Modern immunomorphological aspects of diagnostics of periodontal diseases // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 453-456

For the purpose to determine clinical morphologic features of development of inflammatoty periodontal diseases at women in the postmenopausal period medical examination of 90 patients was carried out. It was established that a postmenopausal osteoporosis is risk factor of development periodontal diseases. In formation of periodontal diseases at women during this period the important role is played hormonal changes
Ostrovskaya L.U., Chanina A.I. Clinical features and some mechanisms of formation of inflammatoty periodontal diseases at women in the postmenopausal period // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 318-319

It is revealed that level decrease slgA at children rheumatic diseases is risk factor of development of plural caries of teeth, and also developments of inflammatory diseases of periodont and an oral cavity mucous membrane. Insufficiency IgAs of a saliva can causes mutual relation infringement between oral cavity microflora, especially its is conditional-pathogenic forms, and an organism of the child
Kozlitina Y.A. Chugaeva U.Y. Admakin O.I. Features of local immunity of an oral cavity at children with rheumatic diseases // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 300-301

As a result of the conducted research results of an estimation of efficiency of application of the general eradication are presented therapy and local therapy at sick of inflammatory periodontal diseases against a chronic gastritis. Authors notice a positive effect at application as pathogenetic therapy of balm for gums of "Asepta" that normalisation of level of hygiene of the oral cavity, proof remission of periodontal diseases against a pathology of a gastroenteric path allows to achieve
Osipova J.L, Bulkina N.V. Estimation of efficiency eradication therapies at sick of inflammatory periodontal diseases against a chronic Helicobacter pylori gastritis // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 282-284