Objective: To determine sensitive and objective criteria of nephrosclerosis by testing the levels of markers of inflammation (MCP-1), fibrogenesis (TGF-(31), renal parenchymal damage (collagen type IV, a-GST, тт-GST), angiogenesis (VEGF) in urine of children with vesicoureteral reflux (VUR). Materials and methods: 80 patients with different stages of VUR have been observed before and 6 months after treatment. Results: «Index of early renal damage» can be found as correlation between VEGF and collagen type IV concentration. Conclusion: Estimation of «index of early renal damage» could be included in pediatric practice for the control of urinary tract dysfunction in children with VUR
Lakomova D.Yu. Index of early renal damage in children with vesicoureteral reflux // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 318-324

The present article summarizes modern conceptions of tubulointerstitial fibrosis development mechanisms in children with vesicoureteral reflux. The review deals with the questions of extracellular matrix components accumulation and disintegration, tissue hypoxia, remodeling of blood flow, concentration changes in inflammation, sclerosis and angiogenesis biomarkers in the progress of nephrosclerosis
Morozov D.A., Morrison V.V., Morozova O.L., Lakomova D.Y. Pathogenic basis and modern prospects in early diagnostics of nephrosclerosis in children with vesicoureteral reflux // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 151-157

The article presents the analysis of perioperative period of 52 children with different variants of correction of vesicoureteral reflux. It was based on acute-phase proteins amount, cytokines level and adhesion molecules content in blood and urine. the study revealed that if the correction is performed during the latent phase of chronic obstructive pyelonephritis the preference should be given to the endoscopic operations as they do not lead to acute inflammatory process in the urinary tract
P.V. Glybochko, A.A. Svistunov, O.L. Morozova, D.A. Morozov, B.V. Dolgov, F.K. Napolnikov Comparative analysis of perioperative period in children with different corrections of vesicoureteral reflux // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 1, 2010, pp. 182-188