Проживание в высоких широтах, в том числе в Евро-Арктическом регионе, предъявляет повышенные требования к психофизиологическому состоянию организма человека, который подвергается специфическому воздействию высокоширотных факторов окружающей среды, приводящих к снижению устойчивости организма и сокращению продолжительности жизни. Цель работы. Определить уровень тревожности и частоту выявления высокой тревожности как проявления психоэмоционального напряжения у студентов в арктических условиях в зависимости от возраста и курса обучения. Материалы и методы. В исследовании приняли участие 133 студентки медицинского колледжа, средний возраст которых составил 21,15±5,89 года. Тестирование психоэмоционального состояния проводилось в соответствии с методикой Ч.Д. Спилбергера-Ю.Л. Ханина. Проводилось ранжирование показателей в зависимости от курса обучения и возраста испытуемых. Результаты. У 33 испытуемых студенток обнаружена высокая ситуативная тревожность (СТ) (25%). Процентное соотношение высокой ситуативной тревожности и её средний уровень снижается к 4 курсу обучения. У многих студенток высокая СТ сохраняется до 4 курса и может быть связана с адаптацией к учебному процессу и проведением контрольных испытаний. В 60% случаев выявлен высокий уровень ЛТ. Высокая ЛТ чаще выявляется в начале обучения и снижается в зависимости от длительности обучения (курса), но у студенток старше 25 лет отмечается рост ЛТ, что можно объяснить сложностями совмещения семейных и трудовых обязанностей с обучением. Заключение. Исследование психоэмоциональной сферы у студенток медицинского колледжа показало, что они представляют группу риска по развитию психоэмоционального напряжения и психосоматических состояний в процессе обучения. Living in high latitudes, including in the Euro-Arctic region, places high demands on the psycho-physiological state of the human body, which is subjected to the specific effects of high-latitude environmental factors leading to a decrease in body resistance and reduced life expectancy. Objective. Determine the level of anxiety and the frequency of detection of high anxiety, as manifestations of psycho-emotional stress among students in Arctic conditions, depending on age and course of study. Subject and methods. The study involved 133 female students, the average age was 21,15±5,89 years. Testing of the psycho-emotional state was carried out in accordance with the method of Ch.D. Spielberger - Yu.L. Hanin. The indicators were ranked according to the course of study and the age of the subjects. Results. 33 anxious students were found to have high anxiety. The frequency of identifying high situational anxiety (SA) in a percentage ratio is 25% and its average level rises to 3 class inclusively and decreases to 4 years of training. High SA in many female students lasts up to 4 class and can be associated with adaptation to the educational process and conducting control tests. In 60% of cases, high levels of personal anxiety (PA) were found. High PA is more often detected at the beginning of training and decreases depending on the length of study (class), but among students over 25 years old there is an increase in PA, which can be explained by the difficulty of combining family and work responsibilities with training. Conclusion. The study of the psycho-emotional sphere of female students of the medical college showed that they represent a risk group for the development of psycho-emotional stress and psychosomatic states in the learning process.
http://vestnikural.ru/article/tom-16-2 10.22138/2500-0918-2019-16-2-195-201

Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in the pathogenesis of different nosologies, as well as analysis of the possible routes of exposure to GPR14 as potential therapeutic targets.

Job is an indispensable part of life. All employees face stress. The health sector has many properties that may lead to stress stemming
from its characteristic structure. Due to the fact that the slightest mistake may lead to loss of human life, satisfaction or dissatisfaction
of employees has an importance not only in terms of individuals but also in terms of the society.
Optimism is a viewpoint. An optimistic person can cope with any difficulties of life and survive dangerous situations with the
smallest loss. Controlling any stressful events is in direct proportion with the optimistic characteristics of an individual, and using
the ways of coping with problems that are focused on solution. Job satisfaction occurs at the point where properties of the job and
expectations and desires of the employee intersect each other. Therefore, establishing a relation between knowledge and skills of
the employee and the properties of the job and leading to the job satisfaction are determinative in terms of ensuring individual and
corporate success.
In todays’ service corporations the increasing importance of competition in the dimension of employees made agreement between
employees and the job more important. Job satisfaction which means a contentment of employee with his/her job, ensures both
spiritual and material satisfaction of employee in his/her job environment, and became a target of both the employee and the corporation
in which the employee works.
It is a fact that the health institutions providing quality working environment for their employees will serve better to their patients.
Songul Yigıt Stress in the Health Sector and Effect of Optimism on the Job Satisfaction // The Russian Academic Journal, Vol. 31, Issue 1, 2015, pp. 0-0

A reaction of biomolecules had been studied, including an effect of albumin molecules on THz electromagnetic waves on frequencies of active cell metabolites (nitrogen oxide 150.176-150.664 GHz and atmospheric oxygen 129.0 GHz). Change of conformational molecule state had been displayed.
Vyacheslav F. Kirichuk, Alexander A. Tsymbal Biological effects of THz electromagnetic waves on frequencies of active cell metabolites at a molecular level // Russian Open Medical Journal, Vol. 2, Issue 4, 2013, pp. 405-0

There had been carried out a comparative analysis of terahertz (THz) radiation exposure of 150.176-150.664 GHz nitrogen oxide occurrences on stress-dependent changes in behavioral reactions of white rats under hypokinetic stress condition. It was found that the radiation fully or partially normalizes behavioral reactions of white male rats under hypokinetic stress condition. The most effective method is persistent 30-minute irradiation.
Vyacheslav F. Kirichuk, Olga N. Antipova, Jana A. Krylova, Evgeny V. Andronov Behavioral reactions of white male rats under stress conditions during the persistent irradiation of THz-band electromagnetic waves of nitrogen oxide occurrence // Russian Open Medical Journal, Vol. 2, Issue 1, 2013, pp. 103-0

This article contains information on principle of operation, technical parameters and possible application of Orbita {transliteration from Russian} apparatus for hemodynamic, fibrinolytic and peripheral perfusion disorders treatment. A single exposure to terahertz waves emitted by Orbita apparatus, corresponding to frequencies of molecular absorption and emission spectra of atmospheric oxygen (129.0 GHz), completely cures coagulant and fibrinolytic disorders of animals with acute immobilization stress. A course of treatment with electromagnetic waves corresponding to frequencies of molecular absorption and emission spectra of nitrogen oxide (150.176 – 150.664) leads to normalization of disrupted peripheral tissue perfusion parameters of animal undergoing treatment and stimulates basal and induced output of nitrogen oxide. This leads to decrease in peripheral vascular resistance to microcirculation and increase in blood flow to microvasculature. Experimental data provided in this article serves as a proof of viability of Orbita apparatus for treatment of coagulant, fibrinolytic and tissue perfusion disorders.
Vyacheslav F. Kirichuk, Alexander A. Tsymbal, Alexey N. Ivanov, Tatyana S. Kiriyazi, Olga N. Antipova, Evgeny V. Andronov, Tatyana S. Velikanova, Vitaly V. Velikanov, Svetlana S. Parshina, Natalia E. Babichenko, Elena V. Ponukalina, Irina V. Smyshlyaeva, Liliana K. Tokaeva, Alexander P. Krenitsyky Correction of disorders in tissue perfusion, blood coagulation and fibrinolysis with Orbita apparatus on terahertz waves of cell metabolites // Russian Open Medical Journal, Vol. 2, Issue 1, 2013, pp. 102-0

Objective The phenomenon of geophagy can be explained as an instinctive desire of an organism to correct material and functional deficiencies using natural miner. This paper discusses the impact of geophagy on behavior and conditioned-reflex activity of Wistar rats subjected to instrumental stress under experimental conditions. Methods Experimental geophagy was simulated by adding zeolite-containing tuff (clinoptilolite) to animal feed, the amount relating to 2% of body mass. Tuff was obtained from areas where animals usually eat subsurface rock. Search activity (SA) of animals and peculiarities of information and emotional stress were studied through the use of a universal problem chamber. Results The results of this experimental study show the negative impact of instrumental stress on laboratory animals, manifested in behavioral dysfunction, in the form of changes in qualitative and quantitative characteristics of search activity. Experimental geophagy contributed to significant improvement in behavioral parameters, confirming the anti-stress effects of the use of natural ingredients. Conclusions These results suggest that, in natural environmental conditions, "edible" rocks serve as an adaptive tool for recovery from various types of environmental stresses, and are an example of self-medication.
Asian Pacific Journal of Tropical Biomedicine, 2014. Vol. 4, №5. P. 362-366.

The purpose of the article is to study the state of cardiovascular system of sportsmen involved in rowing and canoeing, both before and after training. Material et methods: The research has been performed by means of the developed mobile devices that allow non-invasive screening assessment of the potential risk of collapse complications. Results: The article outlines the results of the survey carried out to determine the presence of vagotonic tone with deficient activity supply and abnormal pulse wave that may lead to circulatory collapse in exercise. Conclusion: The technique of pulse wave and vegetative regulation assessment before and after training enables to prevent the circulatory collapse development in stressful physical exertion in sportsmen.
Usanov D.A., Protopopov А.А., SkripalA.V., AveryanovA.P., Kashchavtsev Е.О. State of cardiovascular system during exercise in sportsmen // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 1, 2013, pp. 64-68

Purpose: the study of interrelation between characteristics of psychological profile of elderly patients, level of stress hormones in blood serum and character of IHD course. Materials and Methods. The level of catecholamines and cortisol in blood was investigated in two groups of elderly patients (379 patients) formed according to their psychological profile with the help of Cattell questionnaire. Multispiral coronarography was conducted in patients suffering IHD. Results. The established differences of stress level correlated with the characteristics of the course of IHD at all the examined patients. In spite of various levels and reactions of adaptive hormones on stress situations the prevalence of IHD appeared to be the same in both groups although manifestation and clinical severity of coronary insufficiency varied in patients of different groups. The number of patients suffered myocardial infarction, among them with Q-wave, occurred to be higher in one of the groups despite the fact that changes in their coronary arteries were less expressed. Conclusion. The character of psychological profile causes different stress resistance of patients and leads to various levels of stress hormones in blood serum. Depression can become a marker of severe course of cardiovascular pathology. The character of psychological profile influences the course of IHD.
Prokhorenko I.О., Zarubina Е.G. Influence of personality characteristics on spectrum of catecholamines and course of ischemic heart disease in elderly patients // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 4, 2012, pp. 942-946

The research goal is to examine the correlation between psychological profile of patients of senior age groups, levels of stress hormones — adrenaline and noradrenaline — in blood serum and their pathology character. A psychological profile of 247 patients aged from 55 to 82 years has been established with the help of Kettle test, Tsung self-assessment scale and Spilberger-Khanin scale. The rate of adrenaline and noradrenaline in blood serum in the period of exacerbation of somatic pathology and in the period of relative well-being has been estimated by means of immune-enzyme analysis method. The survey has identified three psychological profiles. The first and third groups are less resistant to stress factors psychological types. They are more likely to develop somatic pathology and depression (37,8 and 53,2% respectively), in comparison with patients of the second group (12,5%). The significant increase of catecholamines has been established among patients of the third type of psychological profile both in the period of exacerbation of somatic pathology and in the period of relative well-being. The article concludes that correlations between psychological personality characteristics, rate of catecholamines and structure of somatic pathology have been worked out
Prokhorenko I.O., Zarubina E.G. Role of personal psychological profiles in somatic pathology development // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 415-418