Ras proteins have been reported to play key role in oncologic diseases. Ras proteins are associated with cellular membranes for its carcinogenic activities through post-translational modifications, including farnesylation. Farnesyltransferase is responsible for a type of Ras membrane targeting, which leads to cancer origin and progression. Inhibitors of farnesyltransferase have been developed as novel anticancer agents. In this review, the role of farnesyltransferase in cancer progression and development has been discussed. Further, the current status of development of farnesyltransferase inhibitors for cancer prevention and treatment has also been reviewed.

Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in the pathogenesis of different nosologies, as well as analysis of the possible routes of exposure to GPR14 as potential therapeutic targets.

Currently, there is growth in the number of cancers. It is not enough to ascertain the reasons of their occurrence. This study examines the accumulation of carcinogenic trace elements in cancer based on the pulse - matrix chemistry, developed by the author. These findings suggest the possibility of controlled output of carcinogens from the body by the excitation of acoustic phonons specific target frequency.
2017 march 12

Delayed fluorescence kinetics of exogenous fluorophores in tumor and normal mice mammary tissue cells was researched. Delayed fluorescence kinetics of fluorophores in two types of cells was researched on in its specific features and regularities. The investigation results are discussed in the context of early fluorescent diagnostics method of tissue pathological states.
Proc. of SPIE Vol. 7999 (2010)

The prostate cancer is a widespread disease in Russia with high growth rate and high death rate. Active work in discovery of methods of early diagnostics of prostate cancer is carrying out. it will allow to increase considerably the efficiency of treatment. the data on topography, structural and functional organization, physiology and regulatory effect of neuroendocrine cells and neuroendocrine hormones and peptides of prostate produced by neuroendocrine cells are presented in the review. Neuroendocrine mechanisms of development, prospects of early diagnostics and prognosis of prostate cancer are analyzed
P.V. Glybochko, V.M. Popkov Neuroendocrine aspects of prostate oncogenesis // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 1, 2010, pp. 164-170

In this overview there is given the information about the diagnostic possibilities of ultrasound and magnetic-resonance tomography of cancer prostate both on early and developed stages of the pathological process.
T.G. Khmara ULTRASOUND AND MAGNETIC-RESONANCE TOMOGRAPHY IN COMPLEX DIAGNOSTICS OF PROSTATE CANCER: AN OVERVIEW // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 1, 2008, pp. 25-28

Influence of the factor of time on the remote results of treatment of patients invasive cancer of a bladder remains enough an actual problem. The group of studying made 541 patient, of them men - 425, women - 116. Middle age of patients at the moment of performance cystectomy has made 64,3 years. The average period of time from the moment of an establishment of the diagnosis before performance cystectomy was equaled 2,1 months (from 0,3 up to 12). The period of time more than 3 months was almost independent criterion (р = 0,057), connected with the worse survival rate of patients in comparison with the period less than 3 months from the beginning of installation of the diagnosis before performance cystectomy.
P.V. Glybochko, A.Y. Korolev, K. Lie INFLUENCE OF DURATION OF THE PREOPERATIVE PERIOD ON THE REMOTE RESULTS OF TREATMENT OF PATIENTS WITH INVASIVE CANCER OF BLADDER // Saratov Journal of Medical Scientific Research, Vol. 3, Issue 3, 2007, pp. 87-90