Purpose: the study of interrelation between characteristics of psychological profile of elderly patients, level of stress hormones in blood serum and character of IHD course. Materials and Methods. The level of catecholamines and cortisol in blood was investigated in two groups of elderly patients (379 patients) formed according to their psychological profile with the help of Cattell questionnaire. Multispiral coronarography was conducted in patients suffering IHD. Results. The established differences of stress level correlated with the characteristics of the course of IHD at all the examined patients. In spite of various levels and reactions of adaptive hormones on stress situations the prevalence of IHD appeared to be the same in both groups although manifestation and clinical severity of coronary insufficiency varied in patients of different groups. The number of patients suffered myocardial infarction, among them with Q-wave, occurred to be higher in one of the groups despite the fact that changes in their coronary arteries were less expressed. Conclusion. The character of psychological profile causes different stress resistance of patients and leads to various levels of stress hormones in blood serum. Depression can become a marker of severe course of cardiovascular pathology. The character of psychological profile influences the course of IHD.
Prokhorenko I.О., Zarubina Е.G. Influence of personality characteristics on spectrum of catecholamines and course of ischemic heart disease in elderly patients // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 4, 2012, pp. 942-946

The research goal is to examine the correlation between psychological profile of patients of senior age groups, levels of stress hormones — adrenaline and noradrenaline — in blood serum and their pathology character. A psychological profile of 247 patients aged from 55 to 82 years has been established with the help of Kettle test, Tsung self-assessment scale and Spilberger-Khanin scale. The rate of adrenaline and noradrenaline in blood serum in the period of exacerbation of somatic pathology and in the period of relative well-being has been estimated by means of immune-enzyme analysis method. The survey has identified three psychological profiles. The first and third groups are less resistant to stress factors psychological types. They are more likely to develop somatic pathology and depression (37,8 and 53,2% respectively), in comparison with patients of the second group (12,5%). The significant increase of catecholamines has been established among patients of the third type of psychological profile both in the period of exacerbation of somatic pathology and in the period of relative well-being. The article concludes that correlations between psychological personality characteristics, rate of catecholamines and structure of somatic pathology have been worked out
Prokhorenko I.O., Zarubina E.G. Role of personal psychological profiles in somatic pathology development // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 415-418