A coarse-graining procedure, which involves averaging time series in non-overlapping windows followed by processing of the obtained multiple data sets, is the initial step in the multiscale entropy computation method. In this paper, we discuss how this procedure can be applied with other methods of time series analysis. Based on extended detrended fluctuation analysis (EDFA), we compare signal processing results for data sets with and without coarse-graining. Using the simulated data provided by the interacting nephrons model, we show how this procedure increases, up to 48%, the distinctions between local scaling exponents quantifying synchronous and asynchronous chaotic oscillations. Based on the experimental data of electrocorticograms (ECoG) of mice, an improvement in differences in local scaling exponents up to 41% and Student’s t-values up to 34% was revealed.
Diagnostics 2023 13(1), 93

Analysis and diagnostics of competing transport processes on the basis of the Bernstein - Russell - Narinyani theorem
Volume 1116 (2020) DOI: 10.1007/978-3-030-37919-3_96

Prostate cancer is one of the most urgent problems of modern oncology. The article provides an overview of the methods of treatment of locally advanced prostate cancer, comparative characteristics, the advantages of both independent and combined methods. The results of multicenter studies have been stated.
Popkov V.M., Kim T.D., Ponukalin A.N. Diagnosis and combined treatment of patients with locally advanced prostate cancer // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 317-322

The aim of the research is to improve the efficiency of diagnosis and treatment of NSAID-induced enteropathy at elderly patients with chronic pain (osteoarthritis, dorsopathy). Material and Methods. 300 elderly with osteoarthritis or dorsopathies regularly (8 weeks or more) receiving diclofenac at 75 mg per day were inspected. Clinical features, morphology, components of the diffuse endocrine system of the small intestine were studied. Results. It is defined, that at elderly patients with regular use of NSAIDs in 25% of cases postbulbar erosive duodenitis, in 75% of cases inflammatory and atrophic changes of the distal duodenum were diagnosed. Diagnosis of NSAID-induced enteropathy at elderly should include faecal calprotectin and morphology analysis of postbulbar area of the duodenum. Use meloxicam and sulfasalazine at older patients helps to eliminate or reduce intestinal dyspepsia, malabsorption, and intestinal inflammation on the results of faecal calprotectin and of histology of the small intestine. Conclusion. Elderly patients are at high-risk group for NSAID-induced enteropathy due to functional disturbances in the neuroendocrine system of the small intestine.
Lipatova Т.Е., Dudaeva N.G. Modern strategy of diagnostics and treatment of NSAID-induced enteropathy in elderly // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 1, 2015, pp. 52-56

The article describes the clinical observation of atypical forms of gonococcal infection (isolated gonococcal pharyngitis in a men) and the complexity of its diagnostics.
Yakupov I.A., Goncharova I.F. The case of gonococcal pharyngitis in practice of dermatovenerologist // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 608-609

The problem of inflammatory diseases of joints is one of the most important issues in the pediatrics. Nowadays the significant attention in this sphere is paid to the search of new accurate criteria of diagnostics. It will help estimate the severity of disease, determine the prognosis, choose the method of treatment and monitoring and evaluate the efficacy of the therapy.
Chernenkov Y.V., Zakharova N.B., Kuzmina А.А., Spivakovsky Y.M. Modern methods of early diagnostics of juvenile arthritis // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 2, 2013, pp. 308-313

Article focuses on the intestinal polyps. Intestinal polyps are considered to be obligatory precancerous diseases of the colon. Risk factors, epidemiology, clinical manifestations and diagnostic methods of polyps have been analyzed. The courses of treatment of colon polyps have been revealed.
Lapteva Е.А., Kozlova I.V., Myalina J.N., Pakhomova A.N. Colon polyps: epidemiology, risk factors, diagnostic criteria and courses of treatment // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 2, 2013, pp. 252-259

The histotypic structure of nodular growths has been morphologically studied after the primary surgery and reinter-vention. The revealed difference may indicate either the new thyroid tissue formation or the initial diagnosis error and inadequate surgery. Histological changes of the thyroid gland are caused by both the external (surgery, anthropogenic influence) and internal (reparative processes, dystrophic changes, hormone biosynthesis disturbance) factors, including iodine metabolism. It results in postoperative goiter development
Kovalenko Yu.V. Postoperative recurrent goiter: disease or complication (review) // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 1, 2012, pp. 152-158