Pathogenesis of oral hygiene, smoking, gestosis, immunosuppression and cytokine disbalance affect inflammatory periodontal diseases in pregnant women. The research goal is to study clinical and immunological features of parodentium and cytokine profile in oral cavity of pregnant women. Material and methods: The condition of parodentium tissues was studied at 240 women with physiological pregnancy and 360 with pregnancy complicadet by gestosis. Re-sults: Freguency and character of inflammatory periodontal diseases in pregnancy were defined. Immune and cytokine disbalance contributed greatly to pathogenesis of inflammatory periodontal diseases at pregnant women. Conclusion: Violations of immune homeostasis at the pregnancy, complicated gestosis, authentically are more expressed that contributes to the development of gingivitis and periodontal disease. The imbalance of cytokines can serve in oral liquid as additional diagnostic and predictive marker of severity of a course of inflammatory periodontal disease.
Dubrovskaya M.V., Eremin O.V., Savina Е.А., Ivashchenko Y.Y., Minasyn A.M. Risk factors of development of inflammatory diseases of parodentium in pregnant women // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 383-386

Literature review contains the analysis of information concerning disturbances in hemostasis system in case of arterial hypertension, frequency rate, risk factors, causes and mechanisms of occurrence. The review states the causes of complications, inadequate treatment effects and arterial hypertension pathogenesis
Agapov l.A., Sadchikov D.V., Prigorodov M.V. Gestosis pathogenesis (review) // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 813-816

The research objective is to decrease the frequency of perinatal complications in mother, fetus and newborn. Methodology used is prospective study. Course of pregnancy, delivery, postnatal period and neonatal period has been studied at 50 women and children (the basic group), at 80 women and children (group of comparison). The state of mi-crocirculation was studied at the I- II trimesters of pregnancy before and after treatment by means of biomicroscopy of vessels of eye conjunctiva by slit lamp with computer data processing. Homocysteine was studied at the I- II trimesters of pregnancy before and after treatment, and children of The control group consisted of 63 pregnant women without complicated anamnesis and with somatic status who gave birth to 63 children. At the I trimester of pregnancy in risk groups of development of gestosis hyperhomocysteinemia, preclinical disturbances of processes of microcirculation were observed. The method of preventive treatment of gestosis in the basic group included anticoagulant - Vessl Due F, vitamin E, essenciale H, folic acid, vitamin B6, vitamin B12. The preventive treatment was directed on stabilization of function of vessel endothelium, improvement of processes of microcirculation leading to decrease in frequency and severity of gestosis, perinatal complications in mother and newborn
O.S. Odnokozova, L.V. Vasilenko, N.I. Zryachkin Course Of Pregnancy, Delivery And Health State Of Newborns After Preventive Treatment Of Gestosis In Pregnant Women Of Risk Group // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 4, 2009, pp. 533-536

Dynamics inspection of pregnant women with gestosis, including analysis of biochemical parameters is carried out. Change of metabolic concentration and activity of enzymes in blood serum depending on gestosis course is revealed. Opportunities of estimation of the given parameters for early gestosis diagnostics are determined.
N.R. Ermakova DYNAMICS OF BIOCHEMICAL PARAMETERS OF BLOOD SERUM AT GESTOSIS // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 1, 2009, pp. 54-56

The decrease of epidermal and transformative growth factors in the process of gestation indicates the deficient development of fetopiacental complex and can be used as a prognosis criterion of the gestosis development from the beginning of pregnancy.
L.U. Davidyan, E.N. Malanina, R.M. Khairullin, A.U. Bogdasarov, V.A. Selifonov PATHOGENETIC SIGNIFICANCE OF GROWTH FACTORS IN THE GESTOSIS DEVELOPMENT (CLINICAL RESEARCH) // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 1, 2009, pp. 51-54

The research deals with the results of mother and fetus immune status investigations and indexes of A, M, G classes of immunoglobulins in mothers venous blood during the last phase of delivery. A comparative analysis of these indexes was made in 2 groups in physiologic pregnancy course and in pregnancy complicated by the development of disgammaglobulinemia in the form of Ig G increase and Ig A, Ig M decrease was observed in pregnant women with gestosis of mild severity. At the same time the index increase of all studies classes of immunoglobulins in funic blood was estimated.
N.P. Chesnokova, S.M. Arkhangelsky, N.N. Yakhamova THE ROLE OF IMMUNE STATUS OF MOTHER AND FETUS IN PATHOGENESIS OF GESTOSIS // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 4, 2008, pp. 26-29

The complex clinical and laboratory researches conducted in groups of the pregnant women with mild case of gestosis, middle serious preeclampsia and with heavys everity of gestosis. Anticoagulation and fibrinolytic activity of a wall of vessels on a background of creation of a short-lived ischemia were examined. Disturbance of a coagulative potential of a blood are actuated development endothelial dysfunction in groups of the pregnant women with middle serious preeclampsia and with heavy severity of gestosis.
G.I. Khripunova, E.V. Ponukalina, G.S. Salakhieva ABOUT THE ROLE OF ENDOTHELIAL DYSFUNCTION IN GESTOSIS DEVELOPMENT // Saratov Journal of Medical Scientific Research, Vol. 3, Issue 3, 2007, pp. 60-62