В данном систематическом обзоре представлены особенности ведения беременности у женщин с пятью ведущими онкопатологиями: с меланомой, раком молочной железы, шейки матки, лимфомой, опухолями желудочно-кишечного тракта. Сочетание беременности и онкологического процесса - особая клиническая ситуация, сопровождающаяся высоким риском прерывания беременности. Злокачественные новообразования в популяции беременных женщин встречаются редко, требуют мультидисциплинарного подхода и высокого уровня знаний специалистов, поэтому часто возникают сложности в верификации диагноза, определении тактики лечения и сроков родоразрешения. Нами было изучено 45 зарубежных и отечественных источников, опубликованных в базе PubMed и медицинских журналах за 2007-2017 гг. по этой тематике.

To examine the cytotoxic activity of congeners of 3-amino-isoquinoline, we performed the phenotypic screening using panel of 60 cell lines and found that (N-(6,7-dimethoxy-1-methyl-isoquinolin-3-yl)-4-{[(1-ethyl-4-methyl-1H-pyrazol-3-yl)methyl]amino}benzamide (4d)) exhibited the significant effect against different tumor cell lines while showing the high activity toward human colorectal cancer HCT-116 cells (IC50 = 18 μm) and human breast cancer T-47D cells (GI50 = 1.9 μm). Virtual screening indicated that these compounds target protein kinases and phosphodiesterases (PDE). However, wet screening among panel of protein kinases did not show any significant activity. By contrast, 50 μm of 4c and 4d inhibited the growth of HKe3-mtKRAS spheroids in the 3D floating (3DF) culture suggesting that 4c and 4d target PDE4B which is selectively upregulated by mtKRAS in 3DF culture.
Chem Biol Drug Des. 2016 Apr;87(4):575-82. doi: 10.1111/cbdd.12691. Epub 2015 Dec 29.

In the paper, the results of experimental investigations on the differences of wool structure of healthy mice and mice with malignant tumor (s) are represented. It is shown that destruction of wool structure happens during pathology development. Quantity of cells of external wool layer and their thickness decrease when the tumor capsule enlarges. Difference is seen even when the tumor is small. The obtained results can be used to improve optical techniques of biomedical diagnostics of cancer diseases.
Journal of Innovative Optical Health Sciences Vol. 8, No. 3 (2015) 1541001

Background: Indian women typically present late at advanced stages of breast cancer when little or no benefit can be derived from any form of therapy. Recent global cancer statistics indicate that incidence of breast cancer is rising and the increase is occurring at a faster rate in populations of the developing countries that hitherto enjoyed low incidence of the disease. This prevailing situation supported by recent data suggesting that health behavior may be influenced by level of awareness about breast cancer, prompted us to design a cross-sectional study to assess the knowledge, attitude and practices of community-dwelling women in South India towards breast cancer. Methodology: Three hundred community-dwelling women from rural and peri-urban neighborhoods in Medchal mandal of Andhra Pradesh province, India were recruited for the study in May and June 2011. Data was collected using interviewer-administered questionnaires designed to elicit socio-demographic information and knowledge, attitude and practices of these women towards breast cancer. Data analysis was carried out using Epi_Info. Results: Study participants had poor knowledge of breast cancer. 21.4% participants knew that breast cancer presents commonly as a painless breast lump. Practice of breast self examination was low; only 4.58% participants were aware of the procedure, and none had clinical breast examination in the past year. Women with higher level of education (X2=33.446, p<0.001) and those who were married (X2=10.176, p<0.05) were significantly more knowledgeable about breast cancer. Conclusion: Community-dwelling women in Medchal mandal have poor knowledge of breast cancer, with minority practicing BSE and none practicing CBE. Educational status appears to be the major determinant of level of knowledge and health behavior among the study participants. We recommend establishment of policy guidelines that will enhance adequate and urgent dissemination of knowledge about breast cancer to all women in South India.

The research work provides current data about prevalence of dysmorphia and mammary glands diseases in adolescent girls
Gumenyuk O.I., Chernenkov Yu.V. Mammary glands diseases in adolescent girls (review) // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 465-470

80 case histories of patients with breast cancer were analyzed. During the preoperative examination with objective and instrumental examination methods used the malignant process was suspected but no morphological verification was received. Physical examination revealed 75% cases of cancer. Roentgenologic evidence of malignant tumor was found in 43.5% women. Ultrasound examination of mammary glands showed that 57.7% of patients had cancer symptoms. Despite the repeated puncture aspiration biopsy, preoperative morphological examination proved to be negative. The reasons of morphological verification failure are connected with technical difficulties and morphological features of tumor structure. Negative malignant process verification necessitated the diagnostic partial mastectomy. To achieve ablasticity ofexcisional biopsyit is necessary to keep 2 cm from the tumor. Staged morphological diagnosis verifies the diagnosis in all patients, allowing to choose the adequate extentof surgical procedures.
S.S. Afanasieva, T.N.Popova, L.F. Zhandarova PECULIARITIES OF MORPHOLOGICAL VERIFICATION IN BREAST CANCER // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 2, 2008, pp. 44-47

In recent years, accumulation of “OMICs” data for topological and functional organization of regulatory networks in a cell provides possibility to identify the potential targets involved in pathological processes and to select the most promising targets for future drug development. We propose an approach for anticancer drug target identification, which using microarray data allows discrete modeling of a regulatory network behavior. The effect of drugs inhibiting particular protein or combination of proteins in regulatory network is analyzed by simulation of blockade of single nodes or their combinations. The method was applied to the four groups of breast cancer: HER2/neu-positive breast carcinomas, ductal carcinoma, invasive ductal carcinoma and/or a nodal metastasis and to the generalized breast cancer. As a result, some promising specific molecular targets and their combinations were identified. Inhibitors of some identified targets are known as potential drugs for therapy of malignant diseases; for some other targets we identified hits in the commercially available samples databases.
SAR and QSAR in Environmental Research, 2009, 20 (7-8), 755-766.