Найдено научных статей и публикаций: 3, для научной тематики: Crohn’s disease
1.
Stavtsev D.S., Astrelina Т.А., Azova M.M., Lebedeva L.L., Pukhlikova T.V., Chumak A.A., Knyazev O.V., Eremin I.I., Gilmutdinova I.R., Kotenko K.V.
- Saratov Journal of Medical Scientific Research , 2014
Aim: to study immunogenetic markers of predisposition to the development and protection for Crohn's disease in adults population of the Moscow region. Material and methods. The study included 53 samples of peripheral blood of patients with Crohn's disease in the Moscow region. The control group w...
Aim: to study immunogenetic markers of predisposition to the development and protection for Crohn's disease in adults population of the Moscow region. Material and methods. The study included 53 samples of peripheral blood of patients with Crohn's disease in the Moscow region. The control group was represented by 1,700 samples of umbilical cord blood is healthy newborns. Revealing HLA antigens at low level performed by SSO method on DynalRELI 48 processor. The results received with ambiguous interpretation was using PCR-SSP method (Ivitrogen). Results. Were found the positive and negative associations of groups of HLA alleles with clinical form, the course of Crohn's disease and response to steroid treatment, in particular revealed that, predisposition to the development for Crohn's disease in women and with sensitivity to steroid treatment in this disease associated allele group C*12, to the characteristic restricting markers such as Crohn's disease include the В 38 and A*11 markers nonrestricting, nonpenetrating noninflammatory type groups are alleles B*56 and C*14 and C*14 is also associated with the risk of Crohn's disease in men, characteristic markers of protection to the development of the disease crown with chronic relapsing and severe clinical course are DQB1*02 and DQB1*03, respectively. Conclusion. These results demonstrate the need for studies of gene polymorphism HLA-system, not only in relation to the disease in general, but in selected patients with clinical groups.
Stavtsev D.S., Astrelina Т.А., Azova M.M., Lebedeva L.L., Pukhlikova T.V., Chumak A.A., Knyazev O.V., Eremin I.I., Gilmutdinova I.R., Kotenko K.V. Immunogenetic markers of Crohn's disease in adults population of the Moscow region // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 4, 2014, pp. 743-749
2.
Malakhinova N.A.
- Saratov Journal of Medical Scientific Research , 2010
The article presents the data of age, manifestation, localization and clinical features of course of Crohn's disease and nonspecific ulcerative colitis. A total of 85 children with Crohn's disease and 101 children with nonspecific ulcerative colitis have been under study...
The article presents the data of age, manifestation, localization and clinical features of course of Crohn's disease and nonspecific ulcerative colitis. A total of 85 children with Crohn's disease and 101 children with nonspecific ulcerative colitis have been under study
Malakhinova N.A. Clinical features of nonspecific ulcerative colitis and Crohn's disease in children // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 650-653
3.
N.N. Mironov, S.V. Nasonov, O.P. Alekseeva, S.V. Krishtopenko
- Saratov Journal of Medical Scientific Research , 2008
15 patients with the endoscopically and morphologically verified diagnosis of the Crohn’s disease and 14 healthy humans at the age of 23- 24 years have been examined. The Crohn’s disease index activity was 235 - 310 units. The possibility highly effective liquid chromatography blood serum use for di...
15 patients with the endoscopically and morphologically verified diagnosis of the Crohn’s disease and 14 healthy humans at the age of 23- 24 years have been examined. The Crohn’s disease index activity was 235 - 310 units. The possibility highly effective liquid chromatography blood serum use for diagnosis of the disease has been studied. A blood serum dried extract has been investigated on the "Milichrome A 02" chromatograph (Novosibirsk, "Econova "joint-stock company). The chromatograms have been treated with the use of a multilevel cluster analysis with a pathologic three-measured state form, differing from a healthy human. A diagnostic sensitivity and accuracy of the method has achieved 100%.
N.N. Mironov, S.V. Nasonov, O.P. Alekseeva, S.V. Krishtopenko CROHN’S DISEASE DIAGNOSTICS IN ACUTE STAGE WITH THE USE OF HIGHLY EFFECTIVE LIQUID CHROMATOGRAPHY BLOOD SERUM // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 2, 2008, pp. 82-85