n/a
C.C. Azodo, O. Ehigiator, A.O. Ehizele, O. Ololo, Ashish Runthala, Amit Kumar Singh, Risqa Rina Darwita, Iwany Amalliah, Alphonsus N. Onyiriuka, Zohair Jamil Gazzaz, Khalid Obeid Dhafar, Abdul Fatah Sindy, Mian Usman Farooq, Shakeel Ahmad Mian, S.R. Kulkarni, К.Р. Ravindra, С. Dhume, P.V. Rataboli, E. Rodrigues, E.E. Rodrigues, Georgi Tomov, L.C. De Castro Rossi, I. Dalben, S.C. Mangini Bocchi, Elena V. Chernyshkova Full English article from Saratov Journal of Medical Scienific Research (2010-2011 years) // Russian Open Medical Journal, Vol. 1, Issue 1, 2012, pp. 106-0

Tropicality. Cardiomyopathies (CMP) are diseases of unknown etiology. CMP are usually diagnosed in late stages of the disease. The search for diagnostic methods for CMP in the early stage is of great importance. The purpose is to determine the character of distribution of polymorph genetic variations rates of angiotensin converting enzyme (ACE), glutathione S- transferase (GSTM 1) among CMP patients and healthy subjects living in the Republic of Bashkortostan and to substantiate their value in CMP pathogenesis. Materials and methods. A total of 67 patients with CMP were included in the study. Out of them, 40 patients were diagnosed with ischemic cardiomyopathy (ICMP) and 27 patients — dilatation cardiomyopathy (DCMP). 110 healthy persons were enrolled in the control group. Results. In the group of patients with ICMP, the genotype DD (x2=4,81; p=0,029) occurred more frequently. In DCMP group, there was also an increase in frequency of DD genotype of polymorph genetic locus of ACE gene (%2=4,046; p=0,044). Conclusion. Genetic analysis of polymorph l/D locus of ACE gene in patients with ICMP and DCMP showed a decrease in occurrence rates of II, ID genotypes, allele I, as well as an increase in DD genotypes and allele D. This is associated with an increased risk for the development of these cardiovascular diseases
Berg A.R., Chepurnaya A.N., Karimov D.О., Viktorova T.V., Nikulicheva V.I., Safuanova G.Sh. Analysis of polymorph genetic variations of angiotensin converting enzyme, glutathione S-transferase in patients with cardiomyopathy // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 224-228

The purpose of this study was to investigate the effect of heavy alcohol consumption on serum Malondialdehyde, homocysteine status and glutathione-S -transferase (GST) activities in alcoholics consuming illicit liquor from lower socioeconomic background attending deaddiction centre. The study was conducted in ninety alcoholic patients consuming illicit liquor from lower socio-economic background attending de-addiction centre and compared to healthy non alcoholic controls (n=90). Serum Malondialdehyde (MDA), serum homocysteine and activities of antioxidant enzyme glutathione-S - transferase (GST) were estimated. Alcoholics consuming illicit liquor attending de-addiction centre displayed significantly higher values of serum MDA concentration, serum homocysteine levels and serum GST activities as compared to their non alcoholic healthy controls belonging to the same socio-economic background. Our results indicate that increase in serum Malondialdehyde (MDA) concentration marker of oxidative stress, serum homocysteine levels and serum glutathione-S-transferase (GST) activities may enhance the susceptibility to vascular diseases in heavy illicit drinkers with poor nutritional status
Kulkarni S.R., Ravindra К.Р., Dhume С., Rataboli P.V., Rodrigues E., Rodrigues E.E. Increased serum homocysteine levels and glutathione-S-transferase activities in alcoholic patients attending de-addiction centre // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 620-624