Cardiomyopathies (CMP) are considered diseases with unknown etiology. CMP are usually diagnosed on the late stages of the disease. It is an important task to seek methods which allow diagnosing CMP on the early stages of development. Aim – to estimate the type of polymorphic variants of angiotensin converting enzyme (ACE), glutathione S-transferase (GSTM1) frequency distribution among the CMP sick and healthy individuals living in the Republic of Bashkortostan, and to substantiate their role in the CMP pathogenesis. Material and Methods – There were 67 CMP sick put under observation. Out of them40 werediagnosed ischemic cardiomyopathy (ICM), and 27 were diagnosed dilated cardiomyopathy (DCM). The control group was made up of 110 practically healthy people. The results.In the ICM sick group the DD genotype (χ2=4.8; p=0.029) was definitely found more frequently, also in case of DCM the increase of DD genotype (χ2=4.0, p=0.044) frequency was ascertained. Conclusion – The genetic analysis of polymorphic locus of I/D ACE gene in the ICM and DCM sick showed decrease in frequency of occurrence II, ID genotypes, I allele and increase of D genotype and D allele which points out the increased risk of these cardiovascular diseases.
Arvid R. Berg, A.N. Chepurnaya, D.O. Karimov, T.V. Viktorova, V.I. Nikulicheva, G.Sh. Safuanova Analysis of gene polymorphic variants of angiotensinconverting enzyme, glutathione S-transferase in cardiomyopathy sick patients // Russian Open Medical Journal, Vol. 1, Issue 3, 2012, pp. 301-0

Tropicality. Cardiomyopathies (CMP) are diseases of unknown etiology. CMP are usually diagnosed in late stages of the disease. The search for diagnostic methods for CMP in the early stage is of great importance. The purpose is to determine the character of distribution of polymorph genetic variations rates of angiotensin converting enzyme (ACE), glutathione S- transferase (GSTM 1) among CMP patients and healthy subjects living in the Republic of Bashkortostan and to substantiate their value in CMP pathogenesis. Materials and methods. A total of 67 patients with CMP were included in the study. Out of them, 40 patients were diagnosed with ischemic cardiomyopathy (ICMP) and 27 patients — dilatation cardiomyopathy (DCMP). 110 healthy persons were enrolled in the control group. Results. In the group of patients with ICMP, the genotype DD (x2=4,81; p=0,029) occurred more frequently. In DCMP group, there was also an increase in frequency of DD genotype of polymorph genetic locus of ACE gene (%2=4,046; p=0,044). Conclusion. Genetic analysis of polymorph l/D locus of ACE gene in patients with ICMP and DCMP showed a decrease in occurrence rates of II, ID genotypes, allele I, as well as an increase in DD genotypes and allele D. This is associated with an increased risk for the development of these cardiovascular diseases
Berg A.R., Chepurnaya A.N., Karimov D.О., Viktorova T.V., Nikulicheva V.I., Safuanova G.Sh. Analysis of polymorph genetic variations of angiotensin converting enzyme, glutathione S-transferase in patients with cardiomyopathy // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 224-228