Одновременная оценка уровней экспрессии генов TLR (прогноз прерывания беременности и выкидыша), наличие или отсутствие инфицированности и/или клинических проявлений урогенитальных инфекций могут быть объективными дополнительными критериями для оценки и прогноза течения беременности при урогенитальных инфекциях, а также для персонализации адекватного их лечения с целью профилактики развития прерывания беременности и выкидыша. Установлена патогенетическая (сочетанная повышенная реакция клеточных рецепторов эпителиальных клеток слизистых на развивающийся плод и инфекционный процесс приводит к прерыванию беременности и выкидышу) и диагностическая роль TLR при урогенитальных инфекциях беременных. При урогенитальных инфекциях у беременных уровни экспрессии генов TLR-2 - 21,2 ОЕ и выше, TLR-4 - 23,0 ОЕ и выше, TLR-8 - 25,7 ОЕ и выше свидетельствуют о высокой степени выраженности инфекционного процесса с клиническими проявлениями урогенитальных инфекций, а при установлении уровней экспрессии генов TLR-8 26 ОЕ и ниже верифицируется хроническое течение урогенитальных инфекций, а при уровнях экспрессии генов TLR-8 выше 26 ОЕ верифицируется острое течение урогенитальных инфекций, уровень TLR-8 выше 28 ОЕ является предиктором наступления прерывания береименности и выкидыша.

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C.C. Azodo, O. Ehigiator, A.O. Ehizele, O. Ololo, Ashish Runthala, Amit Kumar Singh, Risqa Rina Darwita, Iwany Amalliah, Alphonsus N. Onyiriuka, Zohair Jamil Gazzaz, Khalid Obeid Dhafar, Abdul Fatah Sindy, Mian Usman Farooq, Shakeel Ahmad Mian, S.R. Kulkarni, К.Р. Ravindra, С. Dhume, P.V. Rataboli, E. Rodrigues, E.E. Rodrigues, Georgi Tomov, L.C. De Castro Rossi, I. Dalben, S.C. Mangini Bocchi, Elena V. Chernyshkova Full English article from Saratov Journal of Medical Scienific Research (2010-2011 years) // Russian Open Medical Journal, Vol. 1, Issue 1, 2012, pp. 106-0

Aim: to define clinical and etiological, radiation and neurophysiological parameters determining the transformation of disseminated leukoencephalitis to multiple sclerosis in children. Materials and methods: clinical and etiological analysis of leukoencephalitis in 229 children aged 1-17 years old and their catamnesis for 5,5±1,8 years were performed. Morphostructural characteristic was made by brain and spinal cord MRI and multimodal provoked potentials. Results: The development of multiple sclerosis in children was observed in the outcome of leukoencephalitis chronic course in 44,4% of the cases and in 73,3% of the cases of mixed herpes viral infection (Epstein-Barr virus and 6 type herpes virus). Morphostructural features in the cases of leukoencephalitis in children depending on the disease course characterized by the prevalence of edematous and inflammatory character of CNS changes in the cases of an acute course, by demyelinating changes in the cases of a prolonged course, and by degenerative and demyelinating ones in the cases of a chronic course were determined. Administration of etiopathogenetic therapy for leukoencephalitis allows to achieve either a complete recovery or with the deficiency up to 2,5 points by EDSS in 96,6% in the cases of acute and prolonged course, and clinical and radiation remission in 50,1% and recovery in 5,5% in the cases of chronic course.
Lobzin Y.V., Skripchenko N.V., Ivanova G.P., Komantsev V.N. Disseminated leukoencephalitis and multiple sclerosis: cause and effect // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 2, 2013, pp. 170-178

Background: Prevention of accidents and management of exposures in the work environment is an important oc¬cupation health issue. This study objective was to investigate the occupational risk of HIV among Nigerian dental sur¬geons. Methods: This descriptive cross sectional survey of 300 dental surgeons practicing in private and government owned dental centers in Nigeria was conducted from June 2006 to January 2007. Results: Percutaneous injury was recorded among 69.3% of respondents and only 1.2% had Post exposure prophylaxis. Those with abraded skin that will treat patient without additional barrier were 8.6%. Percutaneous injury was positively related to gender, position, additional qualifications (p<0.05). Conclusion: Percutaneous injury is significantly high and low preventive measure at such exposure. Policies, practices, and trainings geared towards protecting and reducing the prevalence of percu¬taneous injury among dental surgeons, and improving post exposure prophylaxis uptake in the event of exposure is a necessity
C.C. Azodo Occupational risk of HIV infection among dental surgeons in Nigerian // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 2, 2010, pp. 357-360