n/a
C.C. Azodo, O. Ehigiator, A.O. Ehizele, O. Ololo, Ashish Runthala, Amit Kumar Singh, Risqa Rina Darwita, Iwany Amalliah, Alphonsus N. Onyiriuka, Zohair Jamil Gazzaz, Khalid Obeid Dhafar, Abdul Fatah Sindy, Mian Usman Farooq, Shakeel Ahmad Mian, S.R. Kulkarni, К.Р. Ravindra, С. Dhume, P.V. Rataboli, E. Rodrigues, E.E. Rodrigues, Georgi Tomov, L.C. De Castro Rossi, I. Dalben, S.C. Mangini Bocchi, Elena V. Chernyshkova Full English article from Saratov Journal of Medical Scienific Research (2010-2011 years) // Russian Open Medical Journal, Vol. 1, Issue 1, 2012, pp. 106-0

Homocysteine is a product of methionine metabolism. Increased levels of homocysteine strengthen oxidizing stress, disturb endothelial function, raise arterial blood pressure and lead to thrombus formation. Homocysteine increases the risk of development of atherosclerosis, coronary heart disease, cerebral and peripheral vessels diseases. By severity it can be compared with smoking and hypercholesterolemia. High levels of homocysteine cause the development of cardiovascular diseases that occur in people who have never suffered from heart attacks. Vitamin B-12 and folate decrease the homocysteine level and convert it into cysteine and methionine
Skvortsov Yu.l., Korolkova A.S. Homocysteine as a risk factor of ischemic heart disease development (review) // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 619-624

The purpose of this study was to investigate the effect of heavy alcohol consumption on serum Malondialdehyde, homocysteine status and glutathione-S -transferase (GST) activities in alcoholics consuming illicit liquor from lower socioeconomic background attending deaddiction centre. The study was conducted in ninety alcoholic patients consuming illicit liquor from lower socio-economic background attending de-addiction centre and compared to healthy non alcoholic controls (n=90). Serum Malondialdehyde (MDA), serum homocysteine and activities of antioxidant enzyme glutathione-S - transferase (GST) were estimated. Alcoholics consuming illicit liquor attending de-addiction centre displayed significantly higher values of serum MDA concentration, serum homocysteine levels and serum GST activities as compared to their non alcoholic healthy controls belonging to the same socio-economic background. Our results indicate that increase in serum Malondialdehyde (MDA) concentration marker of oxidative stress, serum homocysteine levels and serum glutathione-S-transferase (GST) activities may enhance the susceptibility to vascular diseases in heavy illicit drinkers with poor nutritional status
Kulkarni S.R., Ravindra К.Р., Dhume С., Rataboli P.V., Rodrigues E., Rodrigues E.E. Increased serum homocysteine levels and glutathione-S-transferase activities in alcoholic patients attending de-addiction centre // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 620-624