Aims. The research aimed the studying and optimizing of the possibility of measuring microcirculatory of blood fow in human skin by laser Doppler fowmetry (LDF) against the various topographic features of the peripheral blood supply of tissues. Materials and methods. 20 people of the age from 20 to 56 years without signs of skin lesions were examined by the LDF device. The LDF device has two radiation sources in the red light at a wavelength range of 650±30 nm and the near — infrared at a wavelength of 805±50 nm. The radiation was carried out with four receiving fbers arranged at distances of 1, 2, 3 and 4 mm from the illuminating fber. The state of microvasculature was studied at four points of skin — in the middle of the forehead, in the center of the right cheek and the symmetric point on the left cheek and chin area. We calculated the average values of microcirculation, its standard deviation and coeffcient of variation. Conclusions. By varying the distance from the illuminating fber to the receiving fber and the wavelength of incident light the values of the microcirculation in the different areas of healthy skin were estimated by laser Doppler fowmetry method (LDF). Tissue probes, the spatial localization of the LDF signal in the tissues and the effective depth of detection have been estimated by Monte Carlo method. It has been found out during the study that the LDF signal changes are directly related to the structural features of the structure of the microvasculature, the depth and density of functioning capillaries. The given method can be used to diagnose the state of biological object in the normal and pathological conditions, as well as evaluating the effectiveness of the treatment of various dermatoses.

Aims. The research aimed the studying and optimizing of the possibility of measuring microcirculatory of blood fow in human skin by laser Doppler fowmetry (LDF) against the various topographic features of the peripheral blood supply of tissues. Materials and methods. 20 people of the age from 20 to 56 years without signs of skin lesions were examined by the LDF device. The LDF device has two radiation sources in the red light at a wavelength range of 650±30 nm and the near — infrared at a wavelength of 805±50 nm. The radiation was carried out with four receiving fbers arranged at distances of 1, 2, 3 and 4 mm from the illuminating fber. The state of microvasculature was studied at four points of skin — in the middle of the forehead, in the center of the right cheek and the symmetric point on the left cheek and chin area. We calculated the average values of microcirculation, its standard deviation and coeffcient of variation. Conclusions. By varying the distance from the illuminating fber to the receiving fber and the wavelength of incident light the values of the microcirculation in the different areas of healthy skin were estimated by laser Doppler fowmetry method (LDF). Tissue probes, the spatial localization of the LDF signal in the tissues and the effective depth of detection have been estimated by Monte Carlo method. It has been found out during the study that the LDF signal changes are directly related to the structural features of the structure of the microvasculature, the depth and density of functioning capillaries. The given method can be used to diagnose the state of biological object in the normal and pathological conditions, as well as evaluating the effectiveness of the treatment of various dermatoses.

The possibility of a non-invasive estimation of a condition of a vascular and extravasated component of microcir-culation in tissues in patients with perioral dermatitis has been discussed in the research. The formation of disorders of a vascular component in microcirculation in patients with perioral dermatitis has been displayed with the help of an active resonant radiometry. It records a superweak electromagnetic radio emission of biotissues refecting a condition of vascular permeability and of a transcapillary exchange of water activity.