Purpose: an assessment of efficiency of complex treatment of periodontitis at women in a period of postmenopause with the use of zoledronic acid. Material and methods. Examination and treatment of 90 patients with a chronic generalized periodontitis against post-menopausal osteoporosis has been conducted. Material is processed statistically. Results. Application of preparations of zoledronic acid in complex treatment of system osteoporosis and periodontitis allows to reduce the frequency of recurrence of periodontal disease and to improve indicators of bone remodeling. Conclusion. In conclusion it is worth while determining that zoledronic acid in complex therapy of periodontitis is an effective method of drug correction of a mineral exchange before periodontological surgery.
Ostrovskaya L.U., Khanina A.l. Treatment of chronic generalized periodontitis at women in the period of postmenopause // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 1, 2015, pp. 69-73

The research goal is to determine the clinical pathogenetic efficacy of Cycloferon liniment in the combined therapy of periodontitis in patients with subclinical stage of HIV-infection. Medical examination and treatment of 40 patients has been carried out. It is established that use of liniment Cycloferon in the combined treatment of patients with subclinical stage of HIV-infection allows to accelerate process of normalization of lipid peroxidation parameters and antioxidant potential of blood and to decrease infection (herpes symplex virus I, Candida albicans, staphylococcus aureus) in par-odontal recess and evidence of local inflammation. The considered method of therapy has been proved to improve convalescence period and to decrease frequency of parodontitis recurrences
Oseeva А.О., Soboleva L.A., Bulkina N.V., Shuldyakov A.A. Modern approaches to parodontitis therapy in HIV patients // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 910-912

Violations occurring in the microcirculatory bed of periodontal tissue, are leading in the development of periodontal disease. The greatest changes are detected at the level of capillaries - lowering the tone and elasticity of blood vessels, reducing blood flow and the development of periodontal tissue hypoxia as a consequence -the development of the state of hypercoagulability and increased thrombotic events in the periodontal vessels
Kitaeva V.N., Bulkina N.V., Polosukhina E.N., Parfenova S.V., Kobzeva U.A. Investigation of violations of the functional activity of platelets in patients with chronic generalized periodontitis with a view to early diagnosis of periodontal pathology // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 295-297

The aim of the study was to determine the characteristic clinical, instrumental and diagnostic criteria of inflammatory periodontal diseases on the background of chronic cholecystitis with subsequent evaluation of the effectiveness of therapeutic measures using the combined action of the running of an alternating magnetic field and low-intensity helium-neon laser. Application low-intensiti laser radiation and a running variable magnetic field in complex treatment of patients periodontitis with cholecystitis expressed anti-inflammatory action allows to stop quickly inflammatory process in periodontium and to reduce treatment terms
Bulkina N.V., Kropotina A.J., Vulach N.A., Osipova J.L., Albitskaya J.N., Dyakova E.S. Evaluating the effectiveness of the treatment of inflammatory periodontal disease on a background of chronic cholecystitis with the combined effect of the running of the alternating magnetic fields and low-intensity laser radiation // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 223-226

For the purpose to determine the clinical pathogenetic efficacy of Cycloferon liniment in the combined therapy of parodontitis in patients with chronic brucellosis medical examination and treatment of 50 patients was carried out. It was established that use of liniment Cycloferon in the combined treatment of patients with pariodontitis against chronic brucellosis allowed to accelerate process of normalization of parameters of lipid peroxidation and antioxidant potential of blood, to decrease infection load (herpes symplex virus I, candida albicans, staphylococcus aureus) in parodontal recess and evidence of local inflammation with reduction of activity of tumour necrosis and interleukin 1b, that provided acceleration of recovery processes, lowering in frequency of pariodontitis recurrences
L.A. Soboleva, R.R. Syakin, N.V. Bulkina, A.A. Shuldyakov Оptimization of periodontitis treatment in patients with chronic brucellosis infection // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 2, 2010, pp. 403-405

The research goal in to determine clinical and pathogenetic efficacy of Cycloferon liniment in the combined therapy of parodontitis in patients with chronic hepatitis C. Examination and treatment of 50 patients were conducted. It was revealed that the use of Cycloferon liniment in the combined treatment of patients with parodontitis accompanied by chronic hepatitis C allowed to accelerate process of normalization of lipid peroxidation and antioxidant potential of blood, to decrease infectious inflammation (herpes simplex virus I, candida albicans, staphylococcus aureus) in parodontal recess and local inflammation. The described method of treatment provided process of recovery and decrease in frequency of parodontitis recurrences
E.N. Blinnikova, L.A. Soboleva, N.V. Bulkina, A.A. Shuldyakov, A.N. Pospelov Clinical and pathogenetic approaches to development of parodontitis therapy in patients with chronic hepatitis С // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 2, 2010, pp. 322-325

Biochemical changes in oral fluid of patients with chronic generalized parodontitis were investigated; the most informative indices were found out, they were used for estimating complex therapy effectiveness by means of low intensive helium — neon laser radiation and alternating running magnetic field
N.V. Bulkina, V.B. Borodulin, Yu.L. Osipova, A.Yu. Kropotina, O.Yu. Guseva, L.V. Bashkova Biochemical Changes in Saliva of Patients with Chronic Generalized Parodontitis under Combined Action of Alternating Running Magnetic Field and Laser Radiation // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 390-393