The study aimed to identify the initial signs of immune violations at professional athletes with the mitral valve prolapse. Material and methods. For establishment of frequency of occurrence of the mitral valve prolapse as manifestations of a displaziya of connecting fibers among professional athletes 541 persons were surveyed (329 young men and 212 girls), an average age was 22,4±1,2 and 21,3±1,3 years respectively. The athletes were exposed to the echocardiography doppler in a prone position on the left side. The immune status of athletes estimated indicators of cellular and humoral immunity: quantity of leukocytes, lymphocytes, phagocyte activity of leukocytes, T indicators — and V-cellular immunity. Phagocyte activity of leukocytes (monocytes and neutrophils) blood was estimated on an indicator of a phagocyte index — number of leukocytes (at %), capable to phagocyte a test-microbe (epidermal staphylococcus). Results. The mitral valve prolapse was revealed at 132 people (24,4%), 74 young men (22,5%) and 58 girls (27,4%). At athletes with a prolapse (132 people) had changes in the immune system, being shown in decrease of levels of im-munoglobulins, total of leukocytes in comparison with athletes without prolapse are revealed. Conclusions. At athletes with the mitral valve prolapse (especially at girls) in the course of adaptation to long and considerable physical activities changes are more often shown from immune system, than athletes without heart pathology. In particular, the total of leukocytes, level of immunoglobulins A and M decreases.
Maslennikova О.М., Reznichenko Т.А., Firsakova V.Yu. Влияние физических нагрузок на иммунный статус у лиц с пролапсом митрального клапана // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 860-862

The article provides a comparative analysis of the immune status in remote post-operative period in patients subjected either to splenectomy or autolientransplantation or to organ-saving operation on spleen
Masliakov V.V., Kirichuk V.F., Chumanov A.Yu. Splenic trauma: specificity of immune status in remote post-operative period // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 716-719

We studied the phenotype of peripheral blood lymphocytes and serum immunoglobulin concentration in patients with early rheumatoid arthritis and rheumatoid arthritis of more than 12 months duration. Subpopulations of CDIgM+, CD25+, and HLA-DR+ lymphocytes and IgA concentration differed in these groups of patients with rheumatoid arthritis. The count of lymphocytes carrying CDIgM+ and HLA-DR+ receptors correlated with activity of rheumatoid arthritis.
Bull Exp Biol Med. 2006 Jan;141(1):84-6.

The article presents the results of examination of 92 women with inflammatory process of urogenital system and the diagnosis of urogenital clamidiosis made for the first time. It points that the analysis of laboratory indices of both cellular and humoral immunity and antioxidant status of women with urogenital clamidiosis carried out before treatment has shown the active increase of relative ratio of T-cells and suppressor-cytotoxic T-cells and the decrease in their absolute values. The analysis has also revealed the increase of NO-cell subpopulation and concentration of immunoglobulin A and E, and activation of lipid peroxidation in the tendency of tocopherol acetase reduction that causes the significant decrease of body antioxidant protection
F.K. Shebzukhova, T.P. Bondar Immune status and antioxidant protection changes in women with urogenital clamidiosis // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 1, 2010, pp. 111-113

The research deals with the results of mother and fetus immune status investigations and indexes of A, M, G classes of immunoglobulins in mothers venous blood during the last phase of delivery. A comparative analysis of these indexes was made in 2 groups in physiologic pregnancy course and in pregnancy complicated by the development of disgammaglobulinemia in the form of Ig G increase and Ig A, Ig M decrease was observed in pregnant women with gestosis of mild severity. At the same time the index increase of all studies classes of immunoglobulins in funic blood was estimated.
N.P. Chesnokova, S.M. Arkhangelsky, N.N. Yakhamova THE ROLE OF IMMUNE STATUS OF MOTHER AND FETUS IN PATHOGENESIS OF GESTOSIS // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 4, 2008, pp. 26-29

The state of wall thomboresistance, hemocoagulation, rheologic properties of blood and immune status have been investigated in patients after various surgeries on spleen in later postoperative period. It has been estimated that the best results are obtained after organpreserving operations on spleen. Somewhat worse results have been observed after splenectomy and autospleentransplantation. The worst results have been revealed in the group of patients after splenectomy.
V.F. Kirichuk, Y.G. Shapkin, V.V. Maslijkov CHANGES OF MICROCIRCULATION AND IMMUNE STATUS IN LATER POSTOPERATIVE PERIOD AFTER SURGERY ON THE TRAUMATIZED SPLEEN // Saratov Journal of Medical Scientific Research, Vol. 3, Issue 3, 2007, pp. 98-103