There is new information about the mechanism of THz radiation of molecular emission and absorption spectrum (MEAS) of 150.176-150.664 GHz nitrogen oxide occurrence exposure. Organized experiments let us establish the fact that a normalizing effect of THz radiation on microvasculature perfusion and functional endothelium condition in male rats under the acute stress condition is not realized after using of nitrogen oxide synthase (NOS) L-NAME. This shows that endogenic nitrogen oxide and endothelial NOS takes part in mechanisms of potentiation of positive correcting effect of MEAS of 150.176–150.664 GHz nitrogen oxide occurrence on defected parameters of skin microvasculature perfusion, and functional endothelium condition in male rats under the acute immobilization stress condition.
Vyacheslav F. Kirichuk, Evgeny V. Andronov The nitrogen oxide synthase effect in endothelium reaction and change in peripheral perfusion under THz radiation of nitrogen oxide occurrence exposure // Russian Open Medical Journal, Vol. 2, Issue 4, 2013, pp. 406-0

The research aimed to conduct studying of cytoprotective effect of cytoflavinum in thermal traumas of various severity levels. Material and methods – 169 patients were included into the research with thermal burns and with a favorable outcome and the severity of a thermal injury from 30 to 170 points according Frank index. 28 patients received cytoflavinum in a complex therapy in a standard dosage. Results – During the cytoflavinum usage in patients with the severity of a thermal injury more than 60 points by Frank there had been fixed: the decrease of a systemic inflammatory response syndrome (SIRS), reduction of stab neutrophils content, slower decrease of erythrocytes, smaller activation of thrombopoiesis, decrease of concentration of the vascular endothelial growth factor. In the group of patients with thermal injuries less than 60 points who had been receiving cytoflavinum there had not positive effects been fixed. Conclusion – Cytoflavinum is the most effective when the severity of a thermal trauma is more than 60 points by Frank.
Alexey J. Bozhedomov, Vitaliy V. Morrison, Nataliya M. Shulayeva, Victoria V. Nikitina, Inna L. Ivanenko Cytoprotective effect of cytoflavinum in the treatment of thermal injuries of various severity levels // Russian Open Medical Journal, Vol. 1, Issue 3, 2012, pp. 305-0

The purpose of research was studying of cytoprotective effect of cytoflavinum at a thermal trauma of different severity level. Materials and methods. 169 patients with thermal burns with a favorable outcome and gravity of a thermal trauma from 30 to 170 points on Franc were under research. 28 patients took standard dosage of cytoflavinum while complex therapy. Results. Patients with thermal trauma more than 60 points on Franc took Cytoflavinumuse and demonstrated decrease in intensity of system inflammatory response syndrome (SIRS), reduction of band neutrophils portion, lowering of erythrocyte number, smaller activation ofthrombocytopoiesis, dicrease of concentration of vascular endothelial growth factor. Positive effect was not revealed in group of patients with thermal trauma less than 60 points who received cytoflavinum. Conclusion. Use of cytoflavinum was the most effective at thermal trauma gravity more than 60 points on Franc
Bozhedomov A.J., Morrison V.V., Shulaeva N.M., Nikitina V.V., Ivanenko I.L. Cytoprotective effect of cytoflavinum at treatment of thermal injury of various severity level // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 1, 2012, pp. 38-42

The aim of the investigation was to study the level of blood high density lipoproteins (HDL) in the groups of children with different course of diadetes type I in order to find out the dependence of course and complications of diabetes on that level. Materials and methods: Blood high density lipoprotein (HDL) levels were investigated in children and adolescents with diadetes type I, depending on the duration of diadetes type I, age, stage of sexual development, the stage of diabetic nephropathy and levels of plasma endothelin-1 (E-1). Results: Decrease in HDL level with increasing duration of diadetes type I in prepubertate patients, higher indices of HDL cholesterol were determined in girls, especially with impaired puberty. HDL cholesterol was higher in diabetic nephropathy at the stage of proteinuria and high level of blood endothelin-1. Conclusion: The revealed changes were considered to cause deregulation of vascular endothelium as a manifestation of the initial stages of endothelial dysfunction
Panfilova V.N., Taranushkina Т.Е., Salmina А.В., Lobanova S.M., Skuchaeva L.V. High density lipoproteins as indicators of endothelial dysfunction in children with diadetes type I // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 972-975

Homocysteine is a product of methionine metabolism. Increased levels of homocysteine strengthen oxidizing stress, disturb endothelial function, raise arterial blood pressure and lead to thrombus formation. Homocysteine increases the risk of development of atherosclerosis, coronary heart disease, cerebral and peripheral vessels diseases. By severity it can be compared with smoking and hypercholesterolemia. High levels of homocysteine cause the development of cardiovascular diseases that occur in people who have never suffered from heart attacks. Vitamin B-12 and folate decrease the homocysteine level and convert it into cysteine and methionine
Skvortsov Yu.l., Korolkova A.S. Homocysteine as a risk factor of ischemic heart disease development (review) // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 619-624