The research aimed to conduct studying of cytoprotective effect of cytoflavinum in thermal traumas of various severity levels. Material and methods – 169 patients were included into the research with thermal burns and with a favorable outcome and the severity of a thermal injury from 30 to 170 points according Frank index. 28 patients received cytoflavinum in a complex therapy in a standard dosage. Results – During the cytoflavinum usage in patients with the severity of a thermal injury more than 60 points by Frank there had been fixed: the decrease of a systemic inflammatory response syndrome (SIRS), reduction of stab neutrophils content, slower decrease of erythrocytes, smaller activation of thrombopoiesis, decrease of concentration of the vascular endothelial growth factor. In the group of patients with thermal injuries less than 60 points who had been receiving cytoflavinum there had not positive effects been fixed. Conclusion – Cytoflavinum is the most effective when the severity of a thermal trauma is more than 60 points by Frank.
Alexey J. Bozhedomov, Vitaliy V. Morrison, Nataliya M. Shulayeva, Victoria V. Nikitina, Inna L. Ivanenko Cytoprotective effect of cytoflavinum in the treatment of thermal injuries of various severity levels // Russian Open Medical Journal, Vol. 1, Issue 3, 2012, pp. 305-0

The purpose of research was studying of cytoprotective effect of cytoflavinum at a thermal trauma of different severity level. Materials and methods. 169 patients with thermal burns with a favorable outcome and gravity of a thermal trauma from 30 to 170 points on Franc were under research. 28 patients took standard dosage of cytoflavinum while complex therapy. Results. Patients with thermal trauma more than 60 points on Franc took Cytoflavinumuse and demonstrated decrease in intensity of system inflammatory response syndrome (SIRS), reduction of band neutrophils portion, lowering of erythrocyte number, smaller activation ofthrombocytopoiesis, dicrease of concentration of vascular endothelial growth factor. Positive effect was not revealed in group of patients with thermal trauma less than 60 points who received cytoflavinum. Conclusion. Use of cytoflavinum was the most effective at thermal trauma gravity more than 60 points on Franc
Bozhedomov A.J., Morrison V.V., Shulaeva N.M., Nikitina V.V., Ivanenko I.L. Cytoprotective effect of cytoflavinum at treatment of thermal injury of various severity level // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 1, 2012, pp. 38-42