The research aimed to conduct studying of cytoprotective effect of cytoflavinum in thermal traumas of various severity levels. Material and methods – 169 patients were included into the research with thermal burns and with a favorable outcome and the severity of a thermal injury from 30 to 170 points according Frank index. 28 patients received cytoflavinum in a complex therapy in a standard dosage. Results – During the cytoflavinum usage in patients with the severity of a thermal injury more than 60 points by Frank there had been fixed: the decrease of a systemic inflammatory response syndrome (SIRS), reduction of stab neutrophils content, slower decrease of erythrocytes, smaller activation of thrombopoiesis, decrease of concentration of the vascular endothelial growth factor. In the group of patients with thermal injuries less than 60 points who had been receiving cytoflavinum there had not positive effects been fixed. Conclusion – Cytoflavinum is the most effective when the severity of a thermal trauma is more than 60 points by Frank.
Alexey J. Bozhedomov, Vitaliy V. Morrison, Nataliya M. Shulayeva, Victoria V. Nikitina, Inna L. Ivanenko Cytoprotective effect of cytoflavinum in the treatment of thermal injuries of various severity levels // Russian Open Medical Journal, Vol. 1, Issue 3, 2012, pp. 305-0

Purpose: to determine the diagnostic value of procalcitonin in blood serum with probable development of multiple-organ-failure syndrome in thermal injury. Material and Methods. Procalcitonin test has been performed on the 1st, 3d, 7th, 15th and 30th days after the thermal injury. The expression of systemic inflammatory response syndrome (SIRS), leukocytic intoxication index (Lll) calculated according to Ya.Ya. Kalf-Kalif, levels of C-reactive protein, MCP-1, IL-6, VEGF, endothelin, and a number of circulating endothelial cells have been determined. Results. The increased level of procalcitonin (>0,5 ng/ml) in thermal injury has been observed in 42,7% of recovered patients and in 71,3% of dead patients. Conclusion. It has been found out that procalcitonin test in thermal injury may be used as an early marker for patients liable to develop polyorgan insufficiency syndrome.
Morrison V.V., Bozhedomov A.J. Procalcitonin as a diagnostic test for thermal injury // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 61-64

Objective: To develop a method of simulation of infected area and depth-controlled burn wound through the use of laser radiation. Material and methods: The contact surgical fiber laser at heating mode of 220°C within 2 с has been used in a surgical experiment on 50 white lab rats under the control of a thermal imager, copper laser nozzle on the skin of an animal. Burn wounds have been infected. Results: Controlled single laser effect by the developed method helps speed up the simulation and subsequent infection of burn wounds, all layers of the skin. Conclusion. The infected burn wound model is suitable for the development of effective combined surgical treatment.
Dobrejkin Е.А. Experimental substantiation of infected burn wounds of skin in laboratory animals // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 2, 2013, pp. 204-208

The purpose of research was studying of cytoprotective effect of cytoflavinum at a thermal trauma of different severity level. Materials and methods. 169 patients with thermal burns with a favorable outcome and gravity of a thermal trauma from 30 to 170 points on Franc were under research. 28 patients took standard dosage of cytoflavinum while complex therapy. Results. Patients with thermal trauma more than 60 points on Franc took Cytoflavinumuse and demonstrated decrease in intensity of system inflammatory response syndrome (SIRS), reduction of band neutrophils portion, lowering of erythrocyte number, smaller activation ofthrombocytopoiesis, dicrease of concentration of vascular endothelial growth factor. Positive effect was not revealed in group of patients with thermal trauma less than 60 points who received cytoflavinum. Conclusion. Use of cytoflavinum was the most effective at thermal trauma gravity more than 60 points on Franc
Bozhedomov A.J., Morrison V.V., Shulaeva N.M., Nikitina V.V., Ivanenko I.L. Cytoprotective effect of cytoflavinum at treatment of thermal injury of various severity level // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 1, 2012, pp. 38-42

Aim. To study the interrelation between the nature of system metabolic disturbances, rheological properties and cell composition of peripheral blood and the dynamics of the development of alterative and necrotic, regenerative and proliferative processes in a zone of surface thermal injury of the skin. Materials and methods. Complex clinical and laboratory examination of 30 patients suffering from surface burns (first-, second-, and third A degrees) was conducted. Results and conclusion: The examination allowed determining the interrelation of the severity of local destructive changes in a thermal injury zone and the nature of system metabolic disturbances typical for the system inflammatory response syndrome with the degree of lipid peroxidation process activation, insufficient activity of antioxidant blood system, increase in blood viscosity properties and cell composition
Polutova N.V., Chesnokova N.P., Ostrovsky N.V., Newazhai Т.A. Pathogenetic interrelation of disturbances in metabolic status, cell composition and rheological properties of blood in surface thermal injuries, their diagnostic and prognostic significance // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 795-800

The research goal is to study the composition of biological vascular endothelial injury markers in dynamic development of burn disease. Materials and methods: the investigation included 32 patients with thermal burns. The markers of vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1 (MCP-1) and the number of circulating endothelial cells (CECs) were observed. Results: it was revealed that levels of VEGF, MCP-1 and CECs were significantly increased in patients with thermal traumas. Conclusion: VEGF and MCP-1 were proved to be early and prominent vascular endothelial injury markers in burn disease
Morrison V. V., Bozhedomov A. Yu., Zakharova N. В., Podgornova A. V. Diagnostic value of markers of vascular endothe-lial injury in thermal traumas // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 629-632

The research goal is to assess the efficacy of treatment with two new original ointments for burns with experimental pseudomonas infection. Burns have been caused by laser to three groups of white rats (20 animals in each group). In 3 days the wounds were infected with clinical strain of Pseudomonas aeruginosa. The wounds of the first group of rats were treated with ointments № 1, the wounds of the second group of rats — with ointments № 2. The third group did not receive any treatment. In 3, 10 and 14 days period the number of microbial cells in purulent discharge was studied. Then they were grown on meat-peptone agar. The number of colonies was counted. The number of cells in purulent discharge of treated wounds was less, than it was in purulent discharge of untreated wounds. The number of cells in purulent discharge of treated with ointments №1 wounds was higher, than it was in purulent discharge of treated with ointments №2 wounds. The article concludes that the local antimicrobial effect of both ointments is explained by their main components — some essential volatile oils and chloramphenicol
Shub G. М., Alipov V. V., Lebedev М. S., Dobreikin Е.А., Alipov N. V., Pronina E.A., Raikova S. V., Shapoval O. G. Application of new original ointments for treatment of burns with experimental pseudomonas infection // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 523-525