The research purpose is focused on studying the role of protein С system in coagulation component disturbance of hemostasis and fibrinolysis system in patients with different forms of gingivitis. The decrease of protein С and antithrombin inactivity, the decrease ofplasminogen reserve in blood, thrombin time shortening and the resistance of factor Va Via to protein Care watched in patients with different forms of gingivitis. The most marked changes in protein С system may be observed in exacerbation phase of acute and chronic ulcerative generalized gingivitis and chronic catarrhal generalized gingivitis. The reduction of indices of protein С system doesn’t occur in remission phase except in patients with chronic catarrhal ulcera five generalized gingivitis
V.F. Kirichuk, T.V. Simonyan PROTEIN C ROLE IN MICROCIRCULATION DISTURBANCE IN PATIENTS WITH GINGIVITIS // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 2, 2008, pp. 61-63

The present research is focused on defining the role of protein С system in the process of blood coagulation and fibrinolysis in patients suffering from different forms ofperiodontitis. The beginning of specific course of treatment in patients with chronic periodontitis there have been diagnosed disturbances in protein С system, the latter being the reason for blood coagulation disorders, such as: the decrease of protein С activity, the decrease of active factor Va resistance, the increase ofplasminogen reserve, the decrease of total antithrombin blood activity, antithrombin III activity including. The degree of changes in protein С system depends on the severity degree of chronic periodontitis: the more severe disease is the more severe disorders itcauses in protein С system. The most evident symptoms of depression of indices in protein С system were observed in patients with quick-progressive periodontitis. The decrease of protein С activity is caused by its consumption in the process of intravascular blood coagulation is characteristic periodontitis.
V.F. Kirichuk, T.V. Simonyan DISTURBANCES IN PROTEIN C SYSTEM IN PATIENTS SUFFERING FROM PERIODONTITIS // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 1, 2008, pp. 48-51