Хуболов А.М., Толстокоров А.С., Коваленко Ю.В. Результаты лапароскопической пластики гигантских грыж пищеводного отверстия диафрагмы сетчатым эндопротезом./Введение./ Вопрос  выбора наиболее оптимального и эффективного метода оперативного лечения гигантских грыж пищеводного отверстия диафрагмы остается дискутабельным. /Цель работы./ Провести ретроспективный анализ среднесрочных и отдаленных результатов антирефлюксных вмешательств при гигантских грыжах пищеводного отверстия диафрагмы, выявить частоту послеоперационных осложнений. /Методы исследования./ Изучены результаты исследования 38 больных с гигантскими грыжами пищеводного отверстия диафрагмы в различные сроки после операции. Отдаленные результаты хирургического лечения изучены в сроки от 1 до 24 месяцев. /Результаты./ Всем больным были выполнены лапароскопические антирефлюксные операции. Выявлено, что использование синтетических эндопротезов при лапароскопической коррекции гигантских грыж пищеводного отверстия диафрагмы, уменьшает вероятность рецидива патологии, улучшая показатели качества жизни./ Заключение./ Анализ отдаленных результатов оперативного вмешательства, с использованием синтетической сетчатых эксплантов, при гигантских грыжах пищеводного отверстия диафрагмы не выявил истинных анатомических рецидивов и осложнений со стороны пищевода.А.М. Khubolov, A.C. Tolstokorov, Yu.V. Kovalenko. Results of laparascopic repair of giant hiatic hernias with meshThe problem of choosing the most optimal and effective surgical method for treating giant hiatic hernias still remains a point of discussion.  /Purpose of study/. Post-hoc analysis of mid-term and late results of various types of antireflux surgery performed to treat giant hiatic hernias. Studied data and /methods of study/: we have studied results of post-surgery examination of 38 patients diagnosed with giant hiatic hernias, the said examination being performed at various time intervals after surgeries/. /The long-term results of surgical treatment were studied within 1-24 months after the operation./ Results/. All the patients underwent laparascopic antireflux surgery. We found that the use of synthetic reinforcing materials in  laparascopic  surgery for giant hiatic hernias does not have a significant impact on quality of life after surgery, but reduces the risk of relapse. /Conclusions. /In assessing the long-term results, this method is characterized by the absence of true anatomic reccurence and esophageal complications, at use of synthetic reinforcing materials  and can be compared to standard techniques. 
Хуболов А.М., Толстокоров А.С., Коваленко Ю.В. Результаты лапароскопической пластики гигантских грыж пищеводного отверстия диафрагмы сетчатым эндопротезом // Бюллетень медицинских Интернет-конференций, Vol. 5, Issue 12, 2016, pp. 1802-1804

The aim of the research was the study of the cell proliferation indices of the gum epithelial cells in patients with parodentium inflammatory diseases accompanied by gastroesophageal reflux disease (GERD). Material and methods. 160 patients were examined, 60 patients with parodentium inflammatory diseases accompanied by NEGERD, 40 patients with parodentium inflammatory diseases accompanied by GERD. The comparison groups consisted of 40 patients with diseases of parodentium without esophagus pathology and 20 healthy persons. Results. On the basis of the conducted clinical-endoscopic, immune-histological and morphological examinations it was established that gingivitis and periodontitis are successive stages of disturbance of the cellular homeostasis of gum epithelial cells. Conclusion. The enhancement of the processes of proliferation and apoptosis promotes the progression of the structural alterations in the tissues of parodentium and oesophagus and may serve as additional diagnostic and prognostic criteria of the diseases of parodentium accompanied by GERD.
Osipova J.L., Bulkina N.V., Osadchuk М.А., Kvetnoy I.M. The role of epithelial cells proliferation and apoptosis disturbances in pathogenesis of inflammatory diseases of parodentium accompanied by gastroesophageal reflux disease // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 449-453

The goal of this article is to present review of literature data concerning the problem of combined periodontal lesions and chronic diseases of digestive apparatus from clinical and laboratory-instrumental view point. Gastrointestinal diseases are frequently accompanied by pathologic changes of periodontium. The leading part of such syntropy is disturbance of a number of regulative mechanisms: immune and endocrine disbalance; microcirculatory and neurohumoral regulation; psychosomatic relations; changes in metabolism of connective tissues; mineral metabolism; vitamin deficit. Pathology of digestive system promotes oral microflora negative influence on periodontium, gingivitis and periodontitis development by means of decreasing nonspecific resistance of organism. Pathology of gastrointestinal tract is the risk factor for development and unfavorable clinical course of chronic inflammatory periodontal diseases
O.V. Eremin, A.V. Lepilin, I.V. Kozlova, D.V. Kargin Comorbidity Of Periodontal And Gastrointestinal Diseases // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 393-398

The goal of the present research is to define correlation of disease exacerbation risk within the next month and sleep-wake regimen changes in patients with gastroesophageal reflux disease. 40 patients with remission have been examined three times a week to determine qualitative and quantitative indices of sleep characteristic. During the following month the dynamic examination of the mentioned group of patients has been carried out for the purpose of timely acute condition diagnostics. It has been revealed that disturbances of sleep indices, such as late falling asleep, long-term falling asleep, frequency of awakening and unpleasant dreams become unfavorable risk factors for the development of the next recurrence of gastroesophageal reflux disease during the nearest month, but the remission of this disease is significantly connected with falling asleep duration and awakening time.
E.I. Kashkina, R.V. Lyakisheva Disturbance Of Sleep-Wake Regimen As Prognosis Criterion Of Gastroesophageal Reflux Disease Exacerbation // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 355-357

The presence of connective tissue undifferentiated dysplasia syndrome against a background of psychological stress at newly recruited can promote the risk of gastroesophageal reflux disease occurrence. To the utmost, correlation between the gastroesophageal reflux disease and such manifestations of connective tissue undifferentiated dysplasia syndrome as asthenic constitution, chest deformation, Gothic palate and hypermobility of joints was found
S.V. Semenov, E.I. Kashkina FEATURES OF CLINICAL COURSE OF GASTROESOPHAGEAL REFLUX DISEASE IN NEWLY RECRUITED WITH CONNECTIVE TISSUE UNDIFFERENTIATED DYSPLASIA SYNDROME // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 4, 2008, pp. 46-49

The article presents analysis of ratio of biorhythm in patients with gastroesophageal reflux disease and time of clinical symptoms appearance. Itwas determined thatcircadian rhythm, estimated according to Kerdo index, is correlated with appearance of disease symptoms in 24 hours. Taking into consideration its characteristics while managing drug therapy allows to raise therapy’s efficacy.
E.I. Kashkina, R.V. Lyakisheva CHRONOBIOLOGICAL APPROACH TO ESTIMATION OF CLINICAL COURSE AND TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 3, 2008, pp. 52-55