To determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcers medical examination and treatment of 296 patients were carried out. Endoscopic, histological and im-munohistochemical studies were performed in all examined patients. Investigation of interleukin -6, -10, -18 in oral cavity by immunofermental analysis was conducted. It was established that Mexidol use in the combined treatment of patients with periodontitis and peptic ulcer allowed to decrease evidence of local inflammation, to normalize processes of neurohumoral and cytokine regulation, that provided acceleration of recovery processes, decrease in periodontitis recurrences. The statistical programs Exsel и Statistica 6.0 were used in the study. The subsequent analysis of the received data was carried out
Ostrovskaya L.U., Kobzeva U.A., Kharish N.A. Clinical and laboratory substantiation of Mexidol use in complex treatment of periodontitis in patients with peptic ulcers // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 481-485

The aim of research was to study clinical and morphological features of peptic ulcer at men and women of various age. 166 patients with duodenal peptic ulcer (80 men and 86 women) and 138 with stomach peptic ulcer (80 men and 58 women) were inspected. Clinical displays, morphometrical analysis of components of diffuse neuroendocrine system and stomach receptors of sexual hormones were studied. It is defined, that peptic ulcer at women under 40 years has more favorable clinical current, than at men. This is based on local neuroendocrine status with positive shifts of melatonin-, VEGF-, glucagon-like cells. In patients aged upwards 40 clinical features of disease course, local neuroendocrine status are erased both at men and women. In patho-genesis of peptic ulcer infringement of receptors expression of steroid hormones in stomach with hyper expression of androgen receptors at men or decrease in receptors expression of estrogen and progesterone along with increase of expression of androgen receptors at women matters. Forecasting of peptic ulcer can be based not only on traditional criteria, but also on results of dynamic research of androgen receptors expression (at men), androgen-, estrogen and progesterone receptors (at women)
Islamova Е.А., Lipatova Т.Е. Clinical and morphological features of peptic ulcer at men and women // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 575-579

The goal of this article is to present review of literature data concerning the problem of combined periodontal lesions and chronic diseases of digestive apparatus from clinical and laboratory-instrumental view point. Gastrointestinal diseases are frequently accompanied by pathologic changes of periodontium. The leading part of such syntropy is disturbance of a number of regulative mechanisms: immune and endocrine disbalance; microcirculatory and neurohumoral regulation; psychosomatic relations; changes in metabolism of connective tissues; mineral metabolism; vitamin deficit. Pathology of digestive system promotes oral microflora negative influence on periodontium, gingivitis and periodontitis development by means of decreasing nonspecific resistance of organism. Pathology of gastrointestinal tract is the risk factor for development and unfavorable clinical course of chronic inflammatory periodontal diseases
O.V. Eremin, A.V. Lepilin, I.V. Kozlova, D.V. Kargin Comorbidity Of Periodontal And Gastrointestinal Diseases // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 393-398