A survey of data found in scientific articles including the main points, structure, spreading and social importance of metabolic syndrome X as a real predictor of mortality level are presented. The genetic mechanism of insulin resistance and arterial hypertension are revealed. The role of obesity in metabolic syndrome’s forming is discussed.
Т.D. Kolopkova, V.V. Blinova, Yu.l. Skvortsov, V.G. Subbotina METABOLIC SYNDROME X - PANDEMIC OF THE XXI CENTURY // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 3, 2008, pp. 130-134

Comparative analysis of personal response peculiarities of clinically healthy people, who do study in different types of institutes of higher education and patients with arterial hypertension demonstrated that students of medical institutes are mostly exposed to riskof arterial hypertension development, as the model of psychosomatic pathology.
T.M. Dyomina, A.I. Kodochigova, V.F. Kirichuk, A.G. Martynova, E.S. Olenko, E.A. Parshina, E.A. Panteleyeva TYPE OF INSTITUTE OF HIGHER EDUCATION AS PSYCHOSOCIAL PREDICTOR OF ARTERIAL HYPERTENSION DEVELOPMENT // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 3, 2008, pp. 73-76

The questions of diagnostics and classification of cognitive disturbances in 112 patients with hypertensive encephalopathy are considered. The diagnosis of cognitive frustration was based on results of expanded neuropsychological examination with a qualitative and quantitative estimation of the received results. 56 % of the examined patients had the moderate cognitive disturbance syndrome. Neurodinamical-disregulation and primary-dismnestical types have been revealed. Taking into account, that opportunities of treatment and rehabilitation of patients with dementia noware rather limited, the study of predementical forms of cognitive disturbances when therapeutic actions are considered to be the most effective and of great importance.
I.E. Poverennova, E.V. Sevastyanova FEATURES OF COGNITIVE DISTURBANCES AT THE ARTERIAL HYPERTENSIA // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 1, 2008, pp. 88-92

Aim: to study dynamics of the 0,1Hz-componentofthe heart rate variability(HRV) spectrum in patients with arterial hypertension taking fosinopril and atenolol. 49 patients with hypertension were enrolled (age - 46+/-7 years). Fosinopril and atenolol were administered consequently. The power of 0,1 Hz-component of the HRV spectrum was assessed during a passive orthostatic test. Results: In patients taking fosinopril and atenolol comparable decrease of blood pressure was observed. Atenolol caused reliable decrease of a heart rate during orthostatic test. The power dynamics of 0,1Hz-componentwas comparable in patients taking fosinopril and atenolol. Conclusion: fosinopril and atenolol influenced similar on 0,1-Hz mechanisms of vegetative heart control system.
O.V. Shevchenko, A.R. Kiselev, V.I. Gridnev, O.M. Posnenkova, A.N. Strunina, A.A. Svistunov THE DYNAMICS OF 0,1 HZ-COMPONENT OF HEART RATE VARIABILITY AT PATIENTS WITH ARTERIAL HYPERTENSION AT TREATMENT BY FOSINOPRIL AND ATENOLOL // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 1, 2008, pp. 84-87

The aim of the present work was a detailed study of questions connected with the peculiarities ofcircadian blood pressure profile, efficiency of amlodipine in patients with goutand arterial hypertension. We used 24-hour blood pressure monitoring before and after 3-months treatment. Patients with gout showed the disturbances of circadian blood pressure profile (Non-dipper). Prolonged calcium antagonists are the best drugs for the hypertensive patients with gout.
A.P. Rebrov, N.A. Magdeeva AMLODIPINI IN THE MANAGEMENT OF HYPERTENSIVE PATIENTS WITH GOUT // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 1, 2008, pp. 72-75

Aim: to study dynamics of the 0,1Hz-componentofthe heart rate variability(HRV) spectrum in patients with arterial hypertension taking fosinopril and atenolol. 49 patients with hypertension were enrolled (age - 46+/-7 years). Fosinopril and atenolol were administered consequently. The power of 0,1 Hz-component of the HRV spectrum was assessed during a passive orthostatic test. Results: In patients taking fosinopril and atenolol comparable decrease of blood pressure was observed. Atenolol caused reliable decrease of a heart rate during orthostatic test. The power dynamics of 0,1Hz-componentwas comparable in patients taking fosinopril and atenolol. Conclusion: fosinopril and atenolol influenced similar on 0,1-Hz mechanisms of vegetative heart control system.
Saratov Journal of Medical Scientific Reserach, 2008, Vol. 4, Iss. 1, P. 84-87

The research goal is to point out potentiality of clinical audit of care quality carried out by IAS "Register AH" in hypertensive patients followed in Saratov polyclinic. Data of medical cards of 205 hypertensive patients (average age 52,8±9,1 years) followed in Saratov polyclinic have been analyzed with the help of IAS "Register AH" indicators set. Implementation of clinical recommendations on diagnosis, treatment and following-up of hypertensive patients from 2007 till 2008 has been assessed. There was no correspondence between statements of recommendations of diagnostic measures for clinical status, treatment and following-up of hypertensive patients. Clinical aim of treatment to support the principal blood pressure has not been achieved in 85% of patients. The main cause has consisted in the patient's clinical status without taking into account the treatment and dynamic follow-up. Clinical audit has allowed the complex evaluation of medical care process in hypertensive patients followed in the studied polyclinic and allowed to reveal a cause of inappropriate results of care. The use of IAS "Register AH" systematizes medical data contained in ambulatory cards, automatizes the process of obtaining indicators results. It increases the reliability assessments
Saratov Journal of Medical Scientific Research. - 2009. - Vol. 5. - Iss. 4. - P. 548-554

Aim. To study effects of carvedilol and metoprolol on vegetative regulation of heart and microcirculatory vessels in patients with arterial hypertension (HT) of 1-2 degrees and high body mass/obesity. Material and methods. Patients with HT of 1-2 degrees (n=25; aged 51±8 y.o.) were included in the study. Registration of 0,1 Hz-fluctuations in heart rhythm variability and microcirculation change was performed during passive orthostatic test at spontaneous breath (duration of each test stage 10 min). Synchronization of 0,1 Hz-rhythms was estimated by calculation of phases difference and a numerical measure of synchronization. Frequency estimations of heart rhythm variability spectrum were performed in high and low frequency ranges additionaly. Results. Carvedilol and metoprolol have the comparable antihypertensive effect and influence on vegetative regulation of cardiovascular system in patients with HT. Both drugs have negative influence on synchronization of 0,1 Hz-rhythms in initially high systolic blood pressure level (>150 mm Hg). Conclusion. Carvedilol and metoprolol have comparable influence on synchronization of 0,1 Hz-rhythms in cardiovascular system.
Rational Pharmacother. 2009; 3: 55-61

The aim of the investigation was to create an innovative technology of primary medical care for patients with essential hypertension using Internet-system and mobile telephone communication. A computer system for continuous monitoring of outpatients with essential hypertension has been developed (Mobile Monitoring System for Essential Hypertension – MMSEH) The MMSEH algorithms are based on the statements of Russian Recommendations for Prevention, Diagnosis, and Treatment of Essential Hypertension (2004). MMSEH enables collection of the information from the patients generating standard SMS requests. It helps to evaluate blood pressure level, the number of smoked cigarettes, and patient’s weight, i.e. main modified factors, taken into consideration in risk stratification. Thus, a physician is able to follow the daily changes of a patient’s condition online. MMSEH helps a general practitioner to comply with the requirements of the national recommendations on essential hypertension (2004), which enables the treatment of a patient with essential hypertension at the level of modern technologies. The MMSEH protocols of patients monitoring demonstrate all the medical care actions as tables and graphs, which helps a physician to evaluate the process of diagnosis and treatment in a short time. Using MMSEH a physician may monitor substantially larger number of patients, additionally it allows reduction of the number of patients’ visits and the visits duration. The patients who did not reach the target blood pressure despite the treatment receive SMS invitations to visit a doctor in order to make a correction of their lifestyle and medicinal therapy. Thus, an innovative medical technology of primary medical care for the patients with essential hypertension using mobile telephone communication has been developed; such a system has important benefits over the existing scheme of primary medical care for outpatients: - It allows active interaction between a doctor and a patient during life-long health monitoring - It helps a physician to monitor substantially larger number of patients, preventing their excessive visits to a physician. - It helps a general practitioner to comply with the requirements of the national recommendations on essential hypertension, which allows the treatment of a patient with essential hypertension at the level of modern technologies. - It prevents a patient with hypertension from unnecessary visiting a physician, which is important for socially active people. - The system makes a patient an active participant of his treatment, helps him to participate conscientiously in leading a healthy life, which increases his responsibility for his own health.
Abstracts book of II International Moscow Conference «Information and Telemedical Technologies in Healthcare» suppoted by Intel®, Russia, Moscow, October 24-25, 2007: p.203

A new follow-up technology of dynamic out-patient control based on system of mobile monitoring of patients with arterial hypertension (SMMAH) has been created in Saratov Scientific Research Institute of Cardiology. SMMAH is based on exchange of information between patient and doctor with the help of Internet and standard short mobile messages. The aim of the present work is to study the effectiveness of SMMAH for follow-up control of hypertensive patients for the period of 12 months. 79 patients with hypertension aged 49±11 were included in the investigation. Control period lasted 12 months. Control visits were made in the 1st, 6th and 12th months. The number of patients became out of control, its causes, percentage of patients who achieved and maintained target blood pressure (BP) were analyzed after each visit. Data were presented as M (95% confidence interval). As a result in 1 month period of investigation 88,6% of patients regularly used mobile messages, 11% of patients were out of control. In 6 months period 68,4% of participants were under control, 31,6% of patients dropped out. In 12 months period — 67% and 33% of patients accordingly. Target BP was maintained in 87% (77%-96%) of patients in 1 month period, in 78% (66%-90%) of patients in 6 months period and in 68% of patients (53%-84%) in 12 months period. High clinical effectiveness of SMMAH has been proved during the study: 67% of patients have followed prescribed therapy after the investigation period and 68% of them have maintained target BP level.
Saratov Journal of Medical Scientific Research, 2009, Vol. 5, № 3, p. 358-362