The given work summarizes external data and self-obtained results on development and diagnostic of kidney involution modifications. Article discusses definition of "senile kidney" as a clinical and pathomorphological term. Major statements on pathophysiological causes of age-associated renal disorders and their prognosis, specifics of chronic kidney disease in elderly and senile patients have been reviewed. Phenomenon of renal "multimorbidity" in eldely maximizes worsening risk of unmodifiable kidney function.
Denisova Т.Р., Lipatova Т.Е., Chernenkov Yu.V., Nazarov M.l. The senile kidney // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 1, 2015, pp. 46-49

The purpose of the study: to examine age-dependent dynamics of parameters of biochemical screening in long-livers. Material and methods. The study included 201 long-livers divided (Saratov) into two groups: the main group (centenarians) and the control group (90-99 y.o.). Basic parameters of biochemical screening were analyzed. Results. The suited sample of centenarians characterized by significantly lower levels of total cholesterol, triglycerids, glucose and creatinine. All studied parameters progrediently decreased from early long-livers age to centenarians. Maximal rates of age dependencies allowed us to confirm maximal weight of lipids in early longevity and glucose and creatinine in centenarians. Conclusion. All present results are most likely explained by the combined effects of genetic, environmental and "hundred years" factors leading to dynamic remodeling of control systems. Major result of such remodeling is age-dependent optimal level of metabolic factors as a mechanism of successive ageing.
Denisova Т.Р., Malinova L.I., Cherevatova О.М. Age-dependent dynamics of screening metabolic parameters in long-livers and its biophysical estimation // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 1, 2015, pp. 28-31

Present article summarizes the results of long-term studies of cardiovascular health parameters in war veterans of Saratov region admitted to Saratov regional hospital for war veterans. Cardiovascular disease spectrum and its prevalence dynamics were studied in war veterans. Clinical signs and disease course features of cardiovascular pathology were systematized including Great Patriotic War veterans, who successfully had reached the state of longevity.
Lipatova Т.Е., Denisova Т.Р., Shuldyakov V.A., Alipova L.N., Haybekova T.V., Yuanov A.A. Cardiovascular disease prevalence and clinical characteristics in Great Patriotic War veterans // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 1, 2015, pp. 23-27

The article summarizes the results of healthcare management of Great Patriotic War veterans for the last 20 years. This period included approbation and improvement of high-technology science-based and efficient healthcare system for war veterans. Healthcare managerial, medical and diagnostical activities are based on original analytical development including population system approach, biophysical approach to human organism, ageing, and senile and stress-induced disorders.
Lipatova Т.Е., Denisova Т.Р., Shuldyakov V.A., Yuanov А.А., Dudaeva N.G. Science-based healthcare organization for Great Patriotic War veterans // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 1, 2015, pp. 15-19

The results of complete clinical and demographic investigation of Volga Region population of long-livers have been presented. Anthropologic, social, clinical, laboratory and instrumental markers of longevity have been determined.
Danilov A.N., Shuldyakov V.A., Malinova L.I., Ahmadullina L.G., Denisova T.P. Ageing and longevity in Volga region population // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 242-247

Purpose: to study the morphological characteristic of a coronary blood flow and feature of erythronJs system at ischemic heart disease in aged patients. Methods. Morphological and functional characteristics of coronary blood flow (according to the data of selective direct angiocoronarography) and also cytomorphological and functional parameters of peripheral blood flow in aged patients with ischemic heart disease have been used. Results. Statistically reliable differences to parameters of «red» blood are determined. Lowering of erythrocytes has been established in women. The parameters of haemoglobin level, hematocrit and increasing of erythrocyte sedimentation rate was marked in both gender. The gender distinctions of age have been revealed remodeling of coronary arteries. Conclusion. The high probability of erythronJs system participation has been shown namely its peripheral link in process of age remodeling of coronary arteries in aged men with ischemic heart disease
Malinova L.I., Akhmadullina L.G. Morphological characteristics of coronary blood flow and eryithron system in elderly patients with ischemic heart disease // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 228-232

Aim: to estimate the dynamic regulation of cerebral blood flow (CBF) and significance of clinical, and laboratory parameters as a possible markers of CBF violations. Material. 179 elderly patients with arterial hypertension were involved in the study. Transcranial Doppler ultrasonography (Philips Envisor HD, USA) was used for CBF parameters dynamics during orthostatic hypotension. Results. Main directions of CBF parameters changings (Friedman ANOVA p 0,0091 ... 0,012, coeff. of concordance 0,308 ... 0,691) were detected. Gender differences of CBF parameters, as well as blood pressure level influence upon CBF regulation during orthostatic hypertension were studied. Conclusion. Received data allow us to consider gender, controlled or uncontrolled hypertension, cytomorphological parameters of peripheral blood, diuretics usage as clinical, and laboratory markers of dynamic regulation of CBF in elderly patients with arterial hypertension
Malinova L.I., Sadjaya L.A., Tikhonova L.A. Dynamic regulation of cerebral blood flow and it's clinical, and laboratory markers in elderly patients with arterial hypertension // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 842-845

Aim: To estimate the dynamics of intima-media complex in elderly patients with arterial hypertension. Materials: 179 elderly patients with arterial hypertension were involved in the study. Mean intima-media wall thickness (IMT) of common carotid arteries in plaque-free sites and prevalence of plaques were evaluated by B-mode ultrasound investigation (Philips Envisor HD, USA). Results: IMT changing was of nonlinear character, remained stable up to 74 years. Mean rate of the following IMT augmentation was 0.157 mm per year. Frequency of atherosclerotic plaque revealing was significantly increased since the 7th decade. Significant correlation between IMT and systolic, diastolic, mean blood pressure levels or medication spectrum was not revealed. Conclusion: Received data proved significant influence of aging upon IMT enlargement
Sadjaya L.A., Tikhonova LA., Malinova L.I. Age dependent dynamics of intima-media complex thickness in elderly patients with arterial hypertension // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 611-614

The modern data on the lipofuscin role in the processes of intracellular exchange have been analysed in the review. The ambiguity of the interpretation of lipofuscin accumulation according to its importance in involutive and pathological processes has been considered in the study. Nowadays there are no data of morphological character, which allow objectively (in a digital equivalent) to find out the solution of the question about the functional importance of lipofuscin during the ageing of an organism or development of pathological processes.
A.A. Efimov, Maslyakova LIPOFUSCIN ROLE IN INVOLUTIVE AND PATHOLOGICAL PROCESSES // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 1, 2009, pp. 11-115

Research objective is the study of volume variations of arterial and venous vessels of cortical and medullary kidney substances of male and female sexes. Morphological changes in kidneys in the process of ageing have been revealed and have been characterized as a progressive nephrosclerosis.
Asfandiyarov F.R., Kafarov E.S., Trizno M.N. VOLUME VARIATIONS OF ARTERIAL AND VENOUS VESSELS OF CORTICAL AND MEDULLARY KIDNEY SUBSTANCES IN THE PROCESS OF AGEING // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 1, 2009, pp. 15-16