Objective: to study the characteristics of soluble forms of leukocyte membrane molecules and their relationship with disease progression in chronic obstructive pulmonary disease (COPD). Materials and Methods. The study involved 50 patients with COPD. All the patients underwent physical examination, spirometry; serum concentration of antigens sCD54, sCD50, sCD38, sCD25, sCD8, sCD95, sHLA I, sHLA-DR was assessed by ELISA, and the results were compared with serum samples of 30 healthy donors. Results. The level of all soluble forms of membrane molecules of leukocytes decreased in patients with severe COPD. We have found the increased content of the differentiation molecules in patients with moderate COPD, indicating the activation of immune cells during the immune response. Conclusion. There was a correlation between the soluble forms of membrane molecules and impaired pulmonary ventilation, which confirmed the role of immune cells in the pathogenesis of COPD.
Makarova Е.М., Plastinina S.S., Lyubavina N.A., Varvarina G.N., Tyurikova L.V., Saltsev S.G. Soluble forms of leukocyte differentiation antigens in chronic obstructive pulmonary disease and their relation with pulmonary ventilation disorders // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 4, 2015, pp. 530-533

The aim of the study was to determine correlation between arterial blood pressure daily rhythm and daily profile of arterial stiffness in male patients with chronic obstructive pulmonary disease (COPD) and arterial hypertension. Materials et methods: Prospective investigation comprised 45 male patients with COPD and arterial hypertension. Individuals of 40 years younger and 80 years elder, patients with diabetes, stroke, angina pectoris, or heart infarction, vascular diseases, and exacerbation of chronic disease, bronchial and pulmonary diseases of other etiology were excluded from the analyses. Comparison group included 47 patients with essential arterial hypertension and without chronic respiratory diseases closely similar on general parameters with patients from main clinical series. Twenty-four-hour arterial blood pressure monitoring (ABPM) and daily arterial stiffness monitoring were performed using BPLab® MnSDP-2 apparatus (Petr Telegin, Russian Federation). Results: Patients with COPD combined with arterial hypertension with raised arterial stiffness measures prevail over individuals in essential hypertension group. There is pathological alteration of the ABPM circadian rhythm and raised «Pressure load» values in raised arterial stiffness group. Conclusion: We found ABPM raised parameters in patients with COPD and arterial hypertension. It confirms necessity of ABPM in daily arterial stiffness assessment in patients with COPD.
Karoli N.A., Dolishnyaya G.R., Borodkin A.M., Rebrov A.P. Relationship of daily arterial blood pressure monitoring readings and arterial stiffness profile in male patients with chronic obstructive pulmonary disease combined with arterial hypertension // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 2, 2013, pp. 247-252

The characteristics of heart remodeling in patients with chronic obstructive pulmonary diseases ( COPD), associated with coronary heart diseases (CHD) were examined. The changes of structural and functional state of myocardium, intracardiac relationships with associated pathology were under study. The role of blood inflammatory cytokines (IL-6, IL-8, TNF-a) and the level of cell adhesion molecules (ICAM-1, VCAM-1) in exacerbating myocardial dysfunction was clarified.
T.G. Shapovalova, N.V.Shelobanova, M.V. Volkova, A.Yu. Ryabova, L.I. Lekareva Features of The Heart Remodeling in Patients with Chronic Obstructive Pulmonary Diseases, Combined with Coronary Heart Diseases // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 352-355

At present there’s no united opinion about existence of pathogenetic relationship between systemic hypertension and chronic obstructive pulmonary disease (COPD). 24-hour blood pressure monitoring is valuable diagnostic method revealing individual characteristics of daily blood pressure profile in patients with COPD, which determine high risks of damage in target organs.
N.A. Karoli, V.A. Sergeyeva 24-HOUR BLOOD PRESSURE MONITORING IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 1, 2009, pp. 64-67