Монография описывает примеры применения микробных технологий для получения производных из серии азотсодержащих гетероциклов (насыщенных азотсодержащих гетероциклов, азааренов и хинолонов). Предлагаются альтернативные пути синтеза веществ, которые трудно получить с помощью методов органической химии. Микробные технологии синтеза органических соединений могут найти практическое применение в производстве различных лекарственных препаратов. The monography describes examples of the application of microbial technologies for obtaining of derivatives from a series of nitrogen heterocycles (saturated nitrogen heterocycles, azaarenes and quinolones). It is proposed alternative ways for synthesize substances that are difficult to obtain by the methods of organic chemistry. Microbial technologies of synthesis of organic compounds may find out a practical application in the production of various drugs.
Parshikov I.A. Microbial conversions of nitrogenous heterocycles. 2015. M.: Editus, 130 p. (ISBN: 978-5-00058-198-8)

Hydroxylation of the Multiple Bond in 1Benzyl-3-methyl-Δ3-piperideine by Micellar Fungi by Cunninghamella verticillata
Cheminform. 2010. V.29. N 1. http://dx.doi.org/10.1002/chin.199801033

Описана микробная трансформация 4-фенилпирролидина растущими культурами грибов.
Cheminform Abstracts. 2010. V. 29. N 1.

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3-quinolinecarboxylic acid.
FEMS Microbiology Letters. 1999. V.177. N 1. P.131–135.

Pyridine, quinoline, acridine, indole, carbazole, and other heterocyclic nitrogen-containing compounds (azaarenes) can be transformed by cultures of bacteria and fungi to produce a variety of new derivatives, many of which have biological activity. In many cases, the microbial biotransformation processes are regio- and stereoselective so that the transformation products may be useful for the synthesis of new candidate drugs.
Applied Microbiology and Biotechnology. 2012. V.95. N 4. P.871-889, DOI: 10.1007/s00253-012-4220-z

Изучена трансформация аналога лекарственного препарата «Такрин» грибами.
Chemistry of Heterocyclic Compounds. 1994. V.30. N5. P.627-628; Chemical Abstracts 1995, v. 122, 290697j.

The ability of a nonpathogenic fungus, Pestalotiopsis guepini, to metabolize fluoroquinolone antimicrobial agents during growth on poultry litter materials was investigated. Sterilized rice hulls, ground corncobs, and pine shavings in glass jars covered with foil were moistened with sterile water and inoculated with P. guepini. The litter materials then were dosed with norfloxacin and incubated for 20 d. In rice-hull cultures, P. guepini produced 4 metabolites: 7-amino-1-ethyl- 6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid, N-formylnorfloxacin, N-acetylnorfloxacin, and desethylene-N-acetylnorfloxacin. In corncob cultures, the fungus producedN-formylnorfloxacin and N-acetylnorfloxacin. In pine-shavings cultures, there was little growth of the fungus and no metabolism of norfloxacin. The results suggest that fungi that grow on poultry litter may degrade residues of antimicrobial drugs.
J. Appl. Poult. Res. 2004. V.1.3 N2. 235-240

Изучены биопревращения 1-бензил-3-метилпипридина-3 мицелиальными грибами.
Химия гетероциклических соединений. 1997. N5. C.711-712.

Микробиологическая трансформация производных мирценаля
Химия гетероциклических соединений. 1994. N5. C.711; C.A. 1995. v.122, 290613d.

Изучена микробная трансформация лекарства "Димебон"
Mendeleev Commun. 1991. N2. P.42-43.