A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified from culture extracts by high-performance liquid chromatography. The metabolite was identified by mass and nuclear magnetic resonance spectrometry as 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3-quinolinecarboxylic acid.
FEMS Microbiology Letters. 1999. V.177. N 1. P.131–135.

Pyridine, quinoline, acridine, indole, carbazole, and other heterocyclic nitrogen-containing compounds (azaarenes) can be transformed by cultures of bacteria and fungi to produce a variety of new derivatives, many of which have biological activity. In many cases, the microbial biotransformation processes are regio- and stereoselective so that the transformation products may be useful for the synthesis of new candidate drugs.
Applied Microbiology and Biotechnology. 2012. V.95. N 4. P.871-889, DOI: 10.1007/s00253-012-4220-z

Изучена трансформация аналога лекарственного препарата «Такрин» грибами.
Chemistry of Heterocyclic Compounds. 1994. V.30. N5. P.627-628; Chemical Abstracts 1995, v. 122, 290697j.

Изучены биопревращения 1-бензил-3-метилпипридина-3 мицелиальными грибами.
Химия гетероциклических соединений. 1997. N5. C.711-712.

This article describes the microbial conversion of the plant-derived antimalarial drug, artemisinin to 7β-hydroxyartemisinin, 4α-hydroxy-1-deoxoartemisinin, 6β-hydroxyartemisinin and 5β-hydroxyartemisinin, and the conversion of 10-deoxoartemisinin to 5β-hydroxy-10-deoxoartemisinin, 4α-hydroxy-1,10-dideoxoartemisinin, 7β-hydroxy-10-deoxoartemisinin, and 15-hydroxy-10-deoxoartemisinin. Each of these structural hydroxy metabolite variants was produced in quantities suitable for derivatization to produce hundreds of novel substituted derivatives via parallel and combinatorial syntheses. The obtained metabolites were produced through bioconversion by Aspergillus niger, Cunninghamella elegans, Eurotium amstelodami, and Mucor rammanianus.
ISBN 1-9336990-7-8 Editors: Singh, V.K.;Govil, J.N.;Arunachalam, C. Phytochemistry and pharmacology III 2007 pp. 115-138

Монография посвящена методам биотехнологии. В работе описаны примеры применения микробных технологий для получения производных противомалярийных лекарств из ряда азотистых гетероциклов и терпеноидов. Предлагается поиск альтернативных пу¬тей синтеза веществ, которые трудно получить с помощью методов органической химии. Микробные технологии синтеза органических соединений могут найти свое практическое применение в получении различных лекарственных средств. Для научных сотрудников, работающих в области биотехнологии, микробиологии и фармакологии.
ISBN 978-5-905695-04-9 Уфа: Издательство «Инфинити», 2012. – 108 с. УДК 574.24 ББК 28.072 П18