Монография описывает примеры применения микробных технологий для получения производных из серии азотсодержащих гетероциклов (насыщенных азотсодержащих гетероциклов, азааренов и хинолонов). Предлагаются альтернативные пути синтеза веществ, которые трудно получить с помощью методов органической химии. Микробные технологии синтеза органических соединений могут найти практическое применение в производстве различных лекарственных препаратов. The monography describes examples of the application of microbial technologies for obtaining of derivatives from a series of nitrogen heterocycles (saturated nitrogen heterocycles, azaarenes and quinolones). It is proposed alternative ways for synthesize substances that are difficult to obtain by the methods of organic chemistry. Microbial technologies of synthesis of organic compounds may find out a practical application in the production of various drugs.
Parshikov I.A. Microbial conversions of nitrogenous heterocycles. 2015. M.: Editus, 130 p. (ISBN: 978-5-00058-198-8)

The saturated nitrogen-containing heterocyclic compounds include many drugs and compounds that may be used as synthons for the synthesis of other pharmacologically active substances. The need for new derivatives of saturated nitrogen-containing heterocycles for organic synthesis, biotechnology and the pharmaceutical industry, including optically active derivatives, has increased interest in microbial synthesis. This review provides an overview of microbial technologies that can be valuable to produce new derivatives of saturated nitrogen-containing heterocycles, including hydroxylated derivatives. The chemo-, regio- and enantioselectivity of microbial processes can be indispensable for the synthesis of new compounds. Microbial processes carried out with fungi, including Beauveria bassiana, Cunninghamella verticillata, Penicillium simplicissimum, Aspergillus niger and Saccharomyces cerevisiae, and bacteria, including Pseudomonas sp., Sphingomonas sp. and Rhodococcus erythropolis, biotransform many substrates efficiently. Among the biological activities of saturated nitrogen-containing heterocyclic compounds are antimicrobial, antitumor, antihypertensive and anti-HIV activities; some derivatives are effective for the treatment and prevention of malaria and trypanosomiasis, and others are potent glycosidase inhibitors.
Appl. Microbiol. Biotecnol. 2014. V.98. N 4. P. 1497-1506.

This article describes the microbial conversion of the plant-derived antimalarial drug, artemisinin to 7β-hydroxyartemisinin, 4α-hydroxy-1-deoxoartemisinin, 6β-hydroxyartemisinin and 5β-hydroxyartemisinin, and the conversion of 10-deoxoartemisinin to 5β-hydroxy-10-deoxoartemisinin, 4α-hydroxy-1,10-dideoxoartemisinin, 7β-hydroxy-10-deoxoartemisinin, and 15-hydroxy-10-deoxoartemisinin. Each of these structural hydroxy metabolite variants was produced in quantities suitable for derivatization to produce hundreds of novel substituted derivatives via parallel and combinatorial syntheses. The obtained metabolites were produced through bioconversion by Aspergillus niger, Cunninghamella elegans, Eurotium amstelodami, and Mucor rammanianus.
ISBN 1-9336990-7-8 Editors: Singh, V.K.;Govil, J.N.;Arunachalam, C. Phytochemistry and pharmacology III 2007 pp. 115-138