Найдено научных статей и публикаций: 9, для научной тематики: Mexidol
1.
Siprov A.V., Masyagin V.A.
- Saratov Journal of Medical Scientific Research , 2015
The aim of the study is comparative assessment of the influence of separated and combined use of pyrimidine and 3-hydroxypyridine derivatives — xymedon and mexidol on the bone marrow hemopoiesis and peripheral blood quantitative indicators in rats with Walker-256 carcinoma at the doxorubicin and pac...
The aim of the study is comparative assessment of the influence of separated and combined use of pyrimidine and 3-hydroxypyridine derivatives — xymedon and mexidol on the bone marrow hemopoiesis and peripheral blood quantitative indicators in rats with Walker-256 carcinoma at the doxorubicin and paclitaxel chemotherapy. Materials and Methods. Experiments have been carried out on 83 Wistar female rats of weight 150-250 grams. Doxorubicin in a dose of 4mg/kg and paclitaxel in a dose of 6mg/kg were administered intraperitoneally on the 11th day of experiment. Xymedon (100mg/kg) and mexidol (50mg/kg) were administered separately and in combination with each other, starting with the 11th day of experiment for 10 Says. We estimated myelograms and peripheral blood changes on the 14th and 22d day of the experiment. Results. Xymedon normalized differentiation of granulocytopoiesis cells more effectively than mexidol and reduced severity of erythrocytopenia on the 14th day of the experiment. Combination of xymedon and mexidol accelerated granulocytes differentiation more effectively than separated use of these medicines. It was accompanied by more effective increase of neutrophils number in peripheral blood. Despite the increase of poly-chromatophil normocytes number in bone marrow to the 22d day, the erythrocytes number in blood was not differed from one at separated use of these medicines. Conclusion. Myeloprotective effect of xymedon exceeds the effect of mexidol one. The combination of xymedon and mexidol accelerates granulocytes differentiation more effectively than separated use of these medicines.
Siprov A.V., Masyagin V.A. Myeloprotective efficiency of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antineoplastic chemotherapy // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 258-262
2.
Alexander V. Siprov, I.M. Vashurkina, V.A. Masyagin
- Russian Open Medical Journal , 2013
The aim of the study is a comparative analysis of the effect of melatonin (Melaxen) and 3-hydroxypyridine (Mexidol) on antitumor and antimetastatic influence of chemoradiotherapy and oxidative status at mice with Lewis lung carcinoma. Material — Experiments have been organized on 95 mice of C57Bl/6 ...
The aim of the study is a comparative analysis of the effect of melatonin (Melaxen) and 3-hydroxypyridine (Mexidol) on antitumor and antimetastatic influence of chemoradiotherapy and oxidative status at mice with Lewis lung carcinoma. Material — Experiments have been organized on 95 mice of C57Bl/6 line and of 20–22 g in weight. Cyclophosphan has been abdominally administered two times in a dosage of 60 mg/kg within the interval of 120 hours — 20-30 min before radiotherapy. It has been located on the area of initial tumor in a dosage of 2 g at the same time as cyclophosphan injection. Melaxen and Mexidol have been intramuscularly injecting in the dosage of 45 and 50 mg/ kg for 14 days. Antitumor and antimetastatic effect of the applied therapy and changes in the oxidative status of the animals have been estimated. Results — Melaxen and Mexidol do not decrease antitumour and antimetastatic effects of radiotherapy and prevent the activation of free radical processes at animals with tumors. Mexidol was more effective than Melaxen in correction of superoxide dismutase activity in liver. The drugs under the study do not decrease radiotherapy-induced lipid peroxidation in the initial tumor. Conclusion — Melaxen and Mexidol do not decrease the radio therapy efficiency and oxidative status at mice with tumor (on the background of antitumor treatment).
Alexander V. Siprov, I.M. Vashurkina, V.A. Masyagin Comparative evaluation of antioxidant drug influence on a radio therapy efficiency and oxidative status in mice // Russian Open Medical Journal, Vol. 2, Issue 3, 2013, pp. 304-0
3.
Siprov A.V., Kostina Yu.A.
- Saratov Journal of Medical Scientific Research , 2014
The aim of the study is to analyze the influence of combination of pyrimidine and 3-hydroxypyridine derivatives — xymedon and mexidol, in comparison with kardioxane on the myocardial bioelectric activity and arterial pressure level in rats with Walker-256 carcinoma at the doxorubicin and paclitaxel ...
The aim of the study is to analyze the influence of combination of pyrimidine and 3-hydroxypyridine derivatives — xymedon and mexidol, in comparison with kardioxane on the myocardial bioelectric activity and arterial pressure level in rats with Walker-256 carcinoma at the doxorubicin and paclitaxel chemotherapy. Material and Methods. Experiments have been carried out on 100 Wistar female rats of weight of 150-250 grams. Doxorubicin and paclitaxel were administered intraperitoneally in a dosage of 4mg/kg and 6mg/kg respectively on the 11th day of experiment. Xymedon (100mg/kg) and mexidol (50mg/kg) were administered separately and in combination with each other, starting with the 11th day of experiment for 10 days. Kardioxane was injected in the dosage of 80mg/kg 20 min before cytostatics. We estimated a myocardial bioelectric activity and arterial pressure level changes on the 11th and 22d day of the experiment. The results. Xymedon and mexidol combination has limited the development of myocardial electrical instability comparable to kardioxane action. This combination has prevented the appearance of metabolic changes of ischemic genesis in the heart more efficiently than kardioxane. Xymedon and mexidol have normalized QT interval dispersion corrected by heart rate less efficiently than kardioxane. Conclusion. The combination of xymedon and mexidol has reduced cardiotoxicity of antitumor therapy more efficiently than the separated use of these medicines or the use of cardioxane.
Siprov A.V., Kostina Yu.A. Cardioprotective efficiency study of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antitumor chemotherapy // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 2, 2014, pp. 257-261
4.
Baturin V.A., Fisher V.V., Sergeev S.A., Yatsuk I.V.
- Saratov Journal of Medical Scientific Research , 2014
The aim of the study: to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes and the number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area. Material and methods. The intracellular concentration of calcium and magnesium wa...
The aim of the study: to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes and the number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area. Material and methods. The intracellular concentration of calcium and magnesium was measured before the operation, in one, three and five days after the surgery with the help of cytochemical method. Mexidol (100mg) was administered intravenously as a single addition to the standard premedication. Results. After surgery, the intracellular calcium and magnesium content increased. After 24 hours, the magnesium level began to decline, and the calcium content in erythrocytes continued to grow. On day 5, the magnesium concentration in erythrocytes decreased below the initial level, and calcium levels remained significantly elevated. Number of endothelial cells in the blood increased immediately after surgery and magnesium-calcium balance and limits endothelial dysfunction. Mexidol continued growing, reaching a peak on day 5 after surgery. When using mexidol decreased levels of calcium and magnesium levels help prevent falls on the 5th day after surgery, decreased the number of circulating endothelial cells. Conclusion. Mexidol prevents postoperative magnesium violation.
Baturin V.A., Fisher V.V., Sergeev S.A., Yatsuk I.V. The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 167-170
5.
Siprov A.M., Vashurkina I.M., Masyagin V.A.
- Saratov Journal of Medical Scientific Research , 2012
The purpose of the study is to carry out a comparative analysis of the effect of melatonin (melaxen) and of 3-hy-droxypyridine (mexidol) on antitumor and antimetastatic influence of radiotherapy and oxidative status in mice with Lew...
The purpose of the study is to carry out a comparative analysis of the effect of melatonin (melaxen) and of 3-hy-droxypyridine (mexidol) on antitumor and antimetastatic influence of radiotherapy and oxidative status in mice with Lewis lung carcinoma. Material: Experiments have been carried out on 95 mice of the line C57BI/6 and weight of 20-22 grams. Cyclophosphan has been intraabdominally administered two times in a dosage of 60mg/kg within the interval of 120 hours — 20-30 min before radiotherapy. It has been located on the area of initial tumor in a dosage of 2 Gr at the same time as cyclophosphan injection. Melaxen and mexidol have been intramuscularly injected in the dosage of 45 and 50 mg/ kg for 14 days. Antitumor and antimetastatic effect of the applied therapy and changes in the oxidative status of the animals have been estimated. The results: Melaxen and mexidol do not decrease antitumour and antimetastatic effects of radiotherapy and prevent the activation of free radical processes in animals with tumors. Mexidol has been more effective than melaxen in correction of superoxide dismutase activity in liver. The drugss under the study do not decrease radiotherapy-induced lipid peroxidation in the initial tumor. Conclusion: Melaxen and mexidol do not decrease the therapeutic efficiency of radiotherapy and correct oxidative status in mice with tumor following antineoplastic treatment.
Siprov A.M., Vashurkina I.M., Masyagin V.A. Comparative evaluation of influence of drugs with antioxidant effect on therapeutic efficiency of radiotherapy and oxidative status in mice // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 4, 2012, pp. 906-910
6.
Ostrovskaya L.U., Kobzeva U.A., Charish N.A., Mogila A.P.
- Saratov Journal of Medical Scientific Research , 2011
For the purpose to determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcer of stomach and duodenal intestine medical examination and treatment of 296 patients was carried out.
It was established that use of Mexidol in the combined...
For the purpose to determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcer of stomach and duodenal intestine medical examination and treatment of 296 patients was carried out.
It was established that use of Mexidol in the combined treatment of patients with parodontitis against peptic ulcer of stomach and duodenal intestine allowed to decrease infection load (Helicobacter pylori) in parodontal recess and evidence of local inflammation with reduction of activity of interleukin-6, -10, -18, that provided acceleration of recovery processes, lowering in frequency of periodontitis recurrences
Ostrovskaya L.U., Kobzeva U.A., Charish N.A., Mogila A.P. Application mexidol in treatment patients of inflammatory periodontal diseases in the combination to peptic ulcer of stomach and duodenal intestine // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 316-318
7.
Ostrovskaya L.U., Kobzeva U.A., Kharish N.A.
- Saratov Journal of Medical Scientific Research , 2011
To determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcers medical examination and treatment of 296 patients were carried out. Endoscopic, histological and im-munohistochemical studies were performed in all examined patients. Inv...
To determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcers medical examination and treatment of 296 patients were carried out. Endoscopic, histological and im-munohistochemical studies were performed in all examined patients. Investigation of interleukin -6, -10, -18 in oral cavity by immunofermental analysis was conducted. It was established that Mexidol use in the combined treatment of patients with periodontitis and peptic ulcer allowed to decrease evidence of local inflammation, to normalize processes of neurohumoral and cytokine regulation, that provided acceleration of recovery processes, decrease in periodontitis recurrences. The statistical programs Exsel и Statistica 6.0 were used in the study. The subsequent analysis of the received data was carried out
Ostrovskaya L.U., Kobzeva U.A., Kharish N.A. Clinical and laboratory substantiation of Mexidol use in complex treatment of periodontitis in patients with peptic ulcers // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 481-485
8.
A.I. Savlukov, R. N. Kildebekova, R.S. Farshatov
- Saratov Journal of Medical Scientific Research , 2009
The research goal is to study lipid peroxydation and ferments of antioxidant protection in group of patients with an acute alcohol intoxication and their correction by medicaments with antioxidant activity (mexidol, glycine and their combination). Patients with diagnosis of ethanol toxic action of m...
The research goal is to study lipid peroxydation and ferments of antioxidant protection in group of patients with an acute alcohol intoxication and their correction by medicaments with antioxidant activity (mexidol, glycine and their combination). Patients with diagnosis of ethanol toxic action of moderate severity degree were under study. There were 4 groups - receiving standard therapy, standard therapy and glycine, standard therapy and mexidol, patients receiving standard therapy with combination of mexidol and glycine. Clinical condition and changes in system "lipid peroxidation - antioxidant protection» were estimated. The expressed improvement was revealed applying standard therapy with combination of mexidol and glycine
A.I. Savlukov, R. N. Kildebekova, R.S. Farshatov Coorection Of Lipid Peroxydation And Antioxydant Protective System By Mexidol And Glycine In Patients With Acute Ethanol Intoxication // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 4, 2009, pp. 507-510
9.
P.V. Glybochko, A.A. Svistunov, D.N. Khotko, A.N. Ponukalin, A.B. Polozov
- Saratov Journal of Medical Scientific Research , 2009
Research objective is to prove correction possibility of lipid peroxidation and antioxidant system protection in neph-rolithiasis by taking pentoxifylline and mexidol. 158 patients with kidney concretion have been under the research. Distance shock-wave lithotripsy (ESWL) has been carried out. Struc...
Research objective is to prove correction possibility of lipid peroxidation and antioxidant system protection in neph-rolithiasis by taking pentoxifylline and mexidol. 158 patients with kidney concretion have been under the research. Distance shock-wave lithotripsy (ESWL) has been carried out. Structure of stones and antioxidant system state have been investigated in all patients. They have been divided into three groups - control, receiving pentoxifylline and receiving mexidol. Influence of indicated preparations on processes of lipid peroxidation and antioxidant system has been studied in case of different structure of concretion
P.V. Glybochko, A.A. Svistunov, D.N. Khotko, A.N. Ponukalin, A.B. Polozov Influence Of Pentoxifylline And Mexidol On Lipid Peroxidation And Anti-oxidant System In Patients With Urolithiasis // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 4, 2009, pp. 505-507
