The aim of the study is a comparative analysis of the effect of melatonin (Melaxen) and 3-hydroxypyridine (Mexidol) on antitumor and antimetastatic influence of chemoradiotherapy and oxidative status at mice with Lewis lung carcinoma. Material — Experiments have been organized on 95 mice of C57Bl/6 line and of 20–22 g in weight. Cyclophosphan has been abdominally administered two times in a dosage of 60 mg/kg within the interval of 120 hours — 20-30 min before radiotherapy. It has been located on the area of initial tumor in a dosage of 2 g at the same time as cyclophosphan injection. Melaxen and Mexidol have been intramuscularly injecting in the dosage of 45 and 50 mg/ kg for 14 days. Antitumor and antimetastatic effect of the applied therapy and changes in the oxidative status of the animals have been estimated. Results — Melaxen and Mexidol do not decrease antitumour and antimetastatic effects of radiotherapy and prevent the activation of free radical processes at animals with tumors. Mexidol was more effective than Melaxen in correction of superoxide dismutase activity in liver. The drugs under the study do not decrease radiotherapy-induced lipid peroxidation in the initial tumor. Conclusion — Melaxen and Mexidol do not decrease the radio therapy efficiency and oxidative status at mice with tumor (on the background of antitumor treatment).
Alexander V. Siprov, I.M. Vashurkina, V.A. Masyagin Comparative evaluation of antioxidant drug influence on a radio therapy efficiency and oxidative status in mice // Russian Open Medical Journal, Vol. 2, Issue 3, 2013, pp. 304-0

The purpose of the study is to investigate the mechanisms of MMP-7, -13, TIMP-2 and RhoA genes expression in blood cells after ionizing radiation exposure. Material and methods.\Ne had examined blood samples from 27 healthy donors, 32 prostate cancer patients before and after radiotherapy, and 32 Chernobyl liquidators by qRT-PCR method. Result. Our results suggests that the expression of MMP-7, MMP-13 genes in prostate cancer patients with grade 2 (T2N0M0). Probably, these changes were associated with the tumor process development, but no with radiation therapy. RhoA level in blood of liquidators was decreased.
Mikhailov V.F., Zasukhina G.D., Shishkina A.A., Shulenina L.V. ММР and RHOA gene expression in persoms exposed to ionizing radiation // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 780-783

Hypophysis adenomas are mostly spread in the chiasmatic cellular area. They account 18% of all new brain formations, the structure of pituitary adenomas includes prolactinomas in a large number of cases which are manifested by the syndrome of hyperprolactinemia and hormone inactive hypophysis tumours (35%). Somatotropins (13-15%) are lower in frequency, the main clinical feature is acromegalia. One can rarely reveal corticotropins (8-10%), gonadotro-pins (7-9%) and thyrotropins (1%) and their mixed forms. Transsphenoidal surgical interventions are considered to be methods of choice treatment of hypophysis adenomas and other formations in the chiasmatic cellular area. Alternative methods of treatment are conservative. They can be as an addition to microsurgery (radiotherapy)
Zhestikova M.G., Kan Ya.A., Sholomov I.I. Advanced methods of treatment of hypophysis adenoma // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 112-114