Найдено научных статей и публикаций: 2, для научной тематики: Melaxen
1.
Alexander V. Siprov, I.M. Vashurkina, V.A. Masyagin
- Russian Open Medical Journal , 2013
The aim of the study is a comparative analysis of the effect of melatonin (Melaxen) and 3-hydroxypyridine (Mexidol) on antitumor and antimetastatic influence of chemoradiotherapy and oxidative status at mice with Lewis lung carcinoma. Material — Experiments have been organized on 95 mice of C57Bl/6 ...
The aim of the study is a comparative analysis of the effect of melatonin (Melaxen) and 3-hydroxypyridine (Mexidol) on antitumor and antimetastatic influence of chemoradiotherapy and oxidative status at mice with Lewis lung carcinoma. Material — Experiments have been organized on 95 mice of C57Bl/6 line and of 20–22 g in weight. Cyclophosphan has been abdominally administered two times in a dosage of 60 mg/kg within the interval of 120 hours — 20-30 min before radiotherapy. It has been located on the area of initial tumor in a dosage of 2 g at the same time as cyclophosphan injection. Melaxen and Mexidol have been intramuscularly injecting in the dosage of 45 and 50 mg/ kg for 14 days. Antitumor and antimetastatic effect of the applied therapy and changes in the oxidative status of the animals have been estimated. Results — Melaxen and Mexidol do not decrease antitumour and antimetastatic effects of radiotherapy and prevent the activation of free radical processes at animals with tumors. Mexidol was more effective than Melaxen in correction of superoxide dismutase activity in liver. The drugs under the study do not decrease radiotherapy-induced lipid peroxidation in the initial tumor. Conclusion — Melaxen and Mexidol do not decrease the radio therapy efficiency and oxidative status at mice with tumor (on the background of antitumor treatment).
Alexander V. Siprov, I.M. Vashurkina, V.A. Masyagin Comparative evaluation of antioxidant drug influence on a radio therapy efficiency and oxidative status in mice // Russian Open Medical Journal, Vol. 2, Issue 3, 2013, pp. 304-0
2.
Siprov A.M., Vashurkina I.M., Masyagin V.A.
- Saratov Journal of Medical Scientific Research , 2012
The purpose of the study is to carry out a comparative analysis of the effect of melatonin (melaxen) and of 3-hy-droxypyridine (mexidol) on antitumor and antimetastatic influence of radiotherapy and oxidative status in mice with Lew...
The purpose of the study is to carry out a comparative analysis of the effect of melatonin (melaxen) and of 3-hy-droxypyridine (mexidol) on antitumor and antimetastatic influence of radiotherapy and oxidative status in mice with Lewis lung carcinoma. Material: Experiments have been carried out on 95 mice of the line C57BI/6 and weight of 20-22 grams. Cyclophosphan has been intraabdominally administered two times in a dosage of 60mg/kg within the interval of 120 hours — 20-30 min before radiotherapy. It has been located on the area of initial tumor in a dosage of 2 Gr at the same time as cyclophosphan injection. Melaxen and mexidol have been intramuscularly injected in the dosage of 45 and 50 mg/ kg for 14 days. Antitumor and antimetastatic effect of the applied therapy and changes in the oxidative status of the animals have been estimated. The results: Melaxen and mexidol do not decrease antitumour and antimetastatic effects of radiotherapy and prevent the activation of free radical processes in animals with tumors. Mexidol has been more effective than melaxen in correction of superoxide dismutase activity in liver. The drugss under the study do not decrease radiotherapy-induced lipid peroxidation in the initial tumor. Conclusion: Melaxen and mexidol do not decrease the therapeutic efficiency of radiotherapy and correct oxidative status in mice with tumor following antineoplastic treatment.
Siprov A.M., Vashurkina I.M., Masyagin V.A. Comparative evaluation of influence of drugs with antioxidant effect on therapeutic efficiency of radiotherapy and oxidative status in mice // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 4, 2012, pp. 906-910