The purpose of the study was to estimate clinical signs and course of coronary heart disease in long-livers and centenarians. Material and Methods. The study included overall population of Saratov — Engels agglomeration's long-livers (>=90 years old, n=198). Results. The rates of major clinical forms of coronary heart disease were detected: atrial fibrillation — 10.6%, chronic heart failure (with preserved ejection fraction) — 10.1 % and angina — 5.1 %. Myocardial infarction was verified in 9.6% of long-livers. Myocardial scar criteria prevailed over myocardial infarction history. Received data corroborated dissolving phenomena of coronary heart disease and noninsulin dependent diabetes mellitus in long-livers. Gender differences in electrophysiological parameters were detected in long-livers. Centenarians with the history of myocardial infarction preserved a satisfactory level of physical activity. Conclusion. Received data confirm a presence of an excessive security: prevention of coronary heart disease manifestation and progression in longevity. Long-livers should be considered as a natural model of an antiatherogenic factors and mechanisms.
Markova T.Yu., Malinova L.I., Denisova Т.Р. Heart ischemic disease and longevity: unsolved problems // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 1, 2015, pp. 37-41

The results of complete clinical and demographic investigation of Volga Region population of long-livers have been presented. Anthropologic, social, clinical, laboratory and instrumental markers of longevity have been determined.
Danilov A.N., Shuldyakov V.A., Malinova L.I., Ahmadullina L.G., Denisova T.P. Ageing and longevity in Volga region population // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 242-247

Aim: In spite of recent achievements in public health, average lifetime in the Volga region as in whole Russia is rather short. Issues of longevity in the region produce scientific interest by clinical, epidemiological and social characteristics of long-lived persons. Material and methods: In total 167 long-lived persons were examined. Medical, social, psychic, emotional and epidemiological characteristics were assessed. Results: The typical long-lived person of the Volga region was brought out. The high quality of life was revealed. The negative influence of smoking and alcoholism on the longevity was shown. Most of the patients needed communication. Lack of complaints was revealed, patients mentioned only the general weakness. Conclusion: The study has explained new social and demographic features of the Volga region long-livers
Malinova L.I., Shuldyakov V.A., Shuvalov S.S., Denisova T.P. Clinical, epidemiological and social characteristics of long-lived persons of the Volga region industrial centre // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 695-698

Cardiovascular pathology spectrum and dynamics in veterans of Great Patriotic War and aged patients of Volga agricultural and industrial region were studied. Clinical signs and course of cardiovascular pathology in aged patients were determined. A «dissolution» phenomenon of chronic cardiovascular pathology was revealed in patients aged over 100 years
Denisova Т.Р., Malinova L.I., Shuldyakov V.A., Alipova L.N., Shuvalov S.S., Silina T.S. Cardiovascular pathology in veterans of Great Patriotic War and aged patients: spectrum and clinical pattern // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 614-619