Background: Oxidative stress and amyloid deposition are tightly interconnected pathological features of Alzheimer disease. In this respect, both amyloid production and aggregation may be stimulated by oxidative stress and also the increase of pathogenic β-amyloid and its aggregated form lead to oxidative stress progression. Therefore, the search for potential drugs with both antioxidant and antiaggregation properties are of great interest. Methods: In this study, we described the stereospecific synthesis of alkaloid securinine aminoderivatives. Results: We showed that the newly synthesized compounds possess antioxidant and metal-chelating properties. Indeed, we report that one compound has inhibitory effects towards μ-amyloid aggregation. Conclusion: Based on these results, aminoderivatives of securinine scaffold are promising compounds for development of new drugs for the treatment of neurodegenerative diseases.

The aim of the present work was to study the neuroprotective roles of alpha-lipoic acid and superoxide dismutase in focal and total cerebral ischemia in rats. Experiments were performed on Wistar rats (n = 125): 1) to assess neuroprotective effects in conditions of permanent occlusion of the left middle cerebral and left common carotid arteries (n = 26); 2) to study the effects of these agents and their combination on survival in conditions of occlusion of both carotid arteries (n = 81). An infarct-limiting effect was seen in the group in which alpha-lipoic acid was given 30 min before ischemia (p = 0.00004). Administration of superoxide dismutase 30 min before ischemia or alpha-lipoic acid immediately before ischemia did not decrease the size of the necrotic area. Administration of alpha-lipoic acid or the combination of alphalipoic acid and superoxide dismutase led to an increase in the animals’ survival time (p = 0.003, p = 0.013), while use of superoxide dismutase alone produced no increase (p = 0.127). Alpha-lipoic acid induced a neuroprotective effect in focal and total cerebral ischemia. Superoxide dismutase did not have a protective effect in ischemia.
Neuroscience and Behavioral Physiology: V.42, Issue 5 (2012), P. 429-433.

The comparative analysis of efficacy of intranasal and intramuscular application of cortexin in combination with transcranial magnetotherapy in patients with primary open-angle glaucoma was conducted. 102 patients (182 eyes) took part in research with primary open-angle glaucoma of I, II, III stages. The most considerable improvement of visual functions resulted from intramuscular and endonasal introductions of cortexin in combination with transcranial magnetotherapy; and longer stabilization of functional indicators was marked in this group
Shcherbinina I.V., Kamenskikh T.G., Kolbenev I.O. Efficacy of complex treatment of glaucoma optical neuropathy by Cortexin // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 4, 2010, pp. 775-779