The aim of the present work was to study the neuroprotective roles of alpha-lipoic acid and superoxide dismutase in focal and total cerebral ischemia in rats. Experiments were performed on Wistar rats (n = 125): 1) to assess neuroprotective effects in conditions of permanent occlusion of the left middle cerebral and left common carotid arteries (n = 26); 2) to study the effects of these agents and their combination on survival in conditions of occlusion of both carotid arteries (n = 81). An infarct-limiting effect was seen in the group in which alpha-lipoic acid was given 30 min before ischemia (p = 0.00004). Administration of superoxide dismutase 30 min before ischemia or alpha-lipoic acid immediately before ischemia did not decrease the size of the necrotic area. Administration of alpha-lipoic acid or the combination of alphalipoic acid and superoxide dismutase led to an increase in the animals’ survival time (p = 0.003, p = 0.013), while use of superoxide dismutase alone produced no increase (p = 0.127). Alpha-lipoic acid induced a neuroprotective effect in focal and total cerebral ischemia. Superoxide dismutase did not have a protective effect in ischemia.
Neuroscience and Behavioral Physiology: V.42, Issue 5 (2012), P. 429-433.

The research goal is to study the causes of perinatal hypoxic impairments of Central Nervous System (CNS) in fetus and newborn. Risk factors of cerebral ischemia development in fetus and newborn are likely to be found anemia, chronic adnexitis in mothers, threatened abortions, athletic type of pregnant women, loop of cord during the pregnancy course, rapid parturition and acute respiratory diseases during the II and III trimesters of pregnancy
Yakovleva O.V., Muzurova L.V., Zryachkin N.I. Leading factors of cerebral ischemia in newborns // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 4, 2010, pp. 772-774