The aim of the present work was to study the neuroprotective roles of alpha-lipoic acid and superoxide dismutase in focal and total cerebral ischemia in rats. Experiments were performed on Wistar rats (n = 125): 1) to assess neuroprotective effects in conditions of permanent occlusion of the left middle cerebral and left common carotid arteries (n = 26); 2) to study the effects of these agents and their combination on survival in conditions of occlusion of both carotid arteries (n = 81). An infarct-limiting effect was seen in the group in which alpha-lipoic acid was given 30 min before ischemia (p = 0.00004). Administration of superoxide dismutase 30 min before ischemia or alpha-lipoic acid immediately before ischemia did not decrease the size of the necrotic area. Administration of alpha-lipoic acid or the combination of alphalipoic acid and superoxide dismutase led to an increase in the animals’ survival time (p = 0.003, p = 0.013), while use of superoxide dismutase alone produced no increase (p = 0.127). Alpha-lipoic acid induced a neuroprotective effect in focal and total cerebral ischemia. Superoxide dismutase did not have a protective effect in ischemia.
Neuroscience and Behavioral Physiology: V.42, Issue 5 (2012), P. 429-433.

The dynamics of superoxide dismutase activity level under the influence of electromagnetic radiation with spectrum absorption and nitric oxide radiation frequency in Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa has been described. The panoramic spectrometric measuring complex, developed in Saratov Central Scientific Research Institute of Measuring Equipment Public Corporation has been used while carrying out the research. Electromagnetic vibrations of extremely high frequencies stimulated in this complex imitate the structure of molecular spectrum absorption and nitric oxide radiation. The activity of superoxide dismutase has been detected. The most significant changes have been observed under 45 and 60-minute exposition.
E.A. Pronina, G.M. Shub, I.G. Shvidenko Electromagnetic Radiation Influence With Molecular Spectrum Absorption and Nitric Oxide Radiation Frequency on Superoxide Dismutase Bacteria Activity // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 2, 2009, pp. 164-166