Objective — To identify quantitative changes of the deuterium content, the intensity of free radical oxidation and antioxidant status of the blood system, as well as the effect of water with a modified isotope composition with low deuterium content on indicators of free radical oxidation of tissues in laboratory animals under physiological conditions and in inflammatory processes. Materials and methods — The object of the study was blood and homogenates of organs (liver, kidney) of male rats. The basis of the model of oxidative stress was a well-known model of wound healing proposed by L.A. Mamedov based on the surgical treatment of abscess model, and we performed its modification in the course of experimental studies. Determination of deuterium concentration in the plasma was carried out using nuclear magnetic resonance. The method of luminol-dependent H2O2-induced chemiluminescence was used for the detection of relatively unstable chemically active radicals in the plasma. Stable radicals detect by the EPR spectrometry. Results and Conclusion — Thus, it should be noted that blood plasma demonstrates reliable reduction in deuterium concentration when using deuterium depleted water that continues until the values of 90-100 ppm thereafter remaining practically unchanged. At the same time, deuterium depleted water affects prooxidant-antioxidant system of the body reducing the intensity of free radical oxidation and restoring the capacity of the endogenous antioxidant system.
Oxana Artsybasheva, Ekaterina Barysheva, Denis Shashkov, Roman Vlasov, Elena Tekutskaya Changes of oxidation during use the food diet with deuterium depleted water in laboratory animals with purulent inflammation // Russian Open Medical Journal, Vol. 3, Issue 2, 2014, pp. 201-0

There has been studied influence of terahertz waves of molecular and absorption spectrum occurrence of 150.176-150.664 GHz nitrogen oxide on intensity of lipid peroxidation processes and blood antioxidant characteristics in 75 white outbred male-rats of 180-220 g under the immobilization stress condition. The tests were performed with account of lipid peroxidation metabolites – lipid hydroperoxides, malondialdehyde. The states of blood antioxidant activity were peroxide erythrocyte resistance, superoxide dismutase and catalasa, general sulfhydryl groups and vitamin E. There has been displayed that under the influence of the THz-band of 150.176-150.664 GHz nitrogen oxide occurrence there was a total normalization of lipid peroxidation processes and of functional antioxidants activity (on the background of stress at white rats).
Vyacheslav F. Kirichuk, Alexander A. Tsymbal The usage of THz radiation of nitrogen oxide occurrence in blood antioxidant characteristics correction and lipid peroxidation process under stress conditions // Russian Open Medical Journal, Vol. 2, Issue 3, 2013, pp. 303-0

Computer aided prediction of biological activity spectra has been carried out for 50 new thiazolyl and benzothiazolyl derivatives. Predicted activity spectra for different compounds from the set include 1±8 activities with estimated probability to be found more than 50%, which cover both possible therapeutic and adverseyside effects. Experimental data coincide with the prediction for 25 of 39 compounds tested as NSAIDs (64.1%); for 4 of 6 compounds tested as local anaesthetics (66.7%); for 1 compound tested as antioxidants (100%). The concordance that describes the overall percentage of correct predictions equals to 65.2% that is sufficient to use this approach for optimization of biological testing. In particular, the compounds from studied data set will be further tested according to the additional predicted activities. Description of the current version of computer system PASS and feasibility for free testing is available via Internet on http://www.ibmh.msk.su/ PASS.
Quantitative Structure-Activity Relationships, 18 (1) 16-25.