Purpose — Platelet volume indices are associated with poor cardiovascular outcomes. The Duke Treadmill Score (DTS) is a composite index that is based on the results from the exercise test. The purpose of this study was to investigate the relationship between the DTS and platelet volume indices in patients with suspected coronary artery disease (CAD). Methods — A total of 1205 participants were enrolled in the study. Complete blood counts were obtained. All participants underwent an exercise test. The DTS were calculated after exercise. Demographic, clinical and echocardiographic characteristics of the patients were recorded. Results — Platelet distribution width (PDW) and especially mean platelet volume (MPV) values increase with higher DTS risk group irrespective of CAD and risk groups which is also found to be statistically significant (P<0.001). The power of the relation was powerful (r=0.911). A powerful positive relation was found between risk level and PDW (P<0.001, r=0.319). Paralleled with DTS, MPV and PDW values of the patients with CAD, hypertension, diabetes mellitus, smoking and hyperlipidemia were higher compared to those without, while MPV and PDW values were lower for the patients taking beta-blockers, angiotensin-converting-enzyme inhibitors or angiotensin receptor blockers, diuretics, aspirin and statins. When MPV (f1) and PDW (%) values were compared between groups, there was a high statistical significance between most groups. Conclusion — We found an independent association between MPV, PDW and DTS.
Rasim Kutlu, Mehmet Erdem Memetoğlu, Tolkun Muratalievic Murataliev, Kadir Gökhan Saçkan, Hasan Yaşar Relationship between Duke Treadmill Score and platelet volume indices in predicting coronary artery disease // Russian Open Medical Journal, Vol. 4, Issue 4, 2015, pp. 0-0

Background — Mean platelet volume (MPV) is an indicator of platelet activation. The pathophysiology of the primary and secondary Raynaud’s Phenomenon (RP) have not been completely established. The aim of this study was to investigate the relationship between MPV and RP. Materials and Methods — Our study was a prospective randomized study carried out from January 2011 to March 2012. The study group consisted of 39 patients: 27 (70%) patients having primary, 12 (30%) patients having secondary RP. An age-, gender-, and body mass index-matched control group consisted of 40 healthy participants. We compared the MPV in patients with RP and control participants statistically. Results — MPV of RP group was 8.79±1.37 femtoliter (fL) while MPV of control group was 8.39±1.36 fL. Comparison of MPV of RP group and control group showed no difference (p=0.274). The mean of MPV was significantly higher among patients with secondary RP (9.76±1.68 fl) when compared with patients with primary RP (8.37±0.96 fl) (p=0.018). Conclusion — The results of our study suggest that MPV may be used as a marker in secondary RP.
Mehmet Erdem Memetoğlu, Rasim Kutlu, Özge Gülsüm Memetoğlu, Tamer Kehlibar, Mehmet Yılmaz, Rafet Günay, Bülend Ketenci, Mehmet Raşit Güney, Mahmut Murat Demirtaş, Deniz Özel The evaluation of mean platelet volume levels in patients with primary and secondary Raynaud’s Phenomenon // Russian Open Medical Journal, Vol. 3, Issue 1, 2014, pp. 101-0