Purpose — Platelet volume indices are associated with poor cardiovascular outcomes. The Duke Treadmill Score (DTS) is a composite index that is based on the results from the exercise test. The purpose of this study was to investigate the relationship between the DTS and platelet volume indices in patients with suspected coronary artery disease (CAD). Methods — A total of 1205 participants were enrolled in the study. Complete blood counts were obtained. All participants underwent an exercise test. The DTS were calculated after exercise. Demographic, clinical and echocardiographic characteristics of the patients were recorded. Results — Platelet distribution width (PDW) and especially mean platelet volume (MPV) values increase with higher DTS risk group irrespective of CAD and risk groups which is also found to be statistically significant (P<0.001). The power of the relation was powerful (r=0.911). A powerful positive relation was found between risk level and PDW (P<0.001, r=0.319). Paralleled with DTS, MPV and PDW values of the patients with CAD, hypertension, diabetes mellitus, smoking and hyperlipidemia were higher compared to those without, while MPV and PDW values were lower for the patients taking beta-blockers, angiotensin-converting-enzyme inhibitors or angiotensin receptor blockers, diuretics, aspirin and statins. When MPV (f1) and PDW (%) values were compared between groups, there was a high statistical significance between most groups. Conclusion — We found an independent association between MPV, PDW and DTS.
Rasim Kutlu, Mehmet Erdem Memetoğlu, Tolkun Muratalievic Murataliev, Kadir Gökhan Saçkan, Hasan Yaşar Relationship between Duke Treadmill Score and platelet volume indices in predicting coronary artery disease // Russian Open Medical Journal, Vol. 4, Issue 4, 2015, pp. 0-0

The central part of brain infarction (Bl) pathogenesis is hemostatic blood activation. Aim: to study platelet aggregative ability in dynamics of acute Bl at the marked stenosis of cerebral arteries (>50%). Materials and methods. Investigation included 39 patients at acute Bl with average age 73,9±8,3 years. Control group consisted of 18 healthy persons with average age 60,2±6,8 years. Evaluation of platelet aggregation was performed with application of light-transmission aggregometer «SOLAR» (RB) and aggregation inductors — solutions of adenosine diphosphate with concentration of 0,5 и 2,0 umol/l and collagen of 2,0mg/ml concentration. Results. Significant hyperaggregation platelet reaction on the 1 st and 10th days of hospitalization without positive changes under treatment has been revealed. Conclusion. Thus, obtained results prove the necessity of monitoring of individual patients sensitivity to antiplatelet therapy in secondary prevention of ischemic stroke with optical aggregometry and inductors complex.
Stepanova Yu.l., Gontchar I.A., Likchachev S.A. Characteristics of platelet aggregative ability at patients with brain infarction and marked stenosis of cerebral arteries // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 3, 2012, pp. 770-774