Purpose — Platelet volume indices are associated with poor cardiovascular outcomes. The Duke Treadmill Score (DTS) is a composite index that is based on the results from the exercise test. The purpose of this study was to investigate the relationship between the DTS and platelet volume indices in patients with suspected coronary artery disease (CAD). Methods — A total of 1205 participants were enrolled in the study. Complete blood counts were obtained. All participants underwent an exercise test. The DTS were calculated after exercise. Demographic, clinical and echocardiographic characteristics of the patients were recorded. Results — Platelet distribution width (PDW) and especially mean platelet volume (MPV) values increase with higher DTS risk group irrespective of CAD and risk groups which is also found to be statistically significant (P<0.001). The power of the relation was powerful (r=0.911). A powerful positive relation was found between risk level and PDW (P<0.001, r=0.319). Paralleled with DTS, MPV and PDW values of the patients with CAD, hypertension, diabetes mellitus, smoking and hyperlipidemia were higher compared to those without, while MPV and PDW values were lower for the patients taking beta-blockers, angiotensin-converting-enzyme inhibitors or angiotensin receptor blockers, diuretics, aspirin and statins. When MPV (f1) and PDW (%) values were compared between groups, there was a high statistical significance between most groups. Conclusion — We found an independent association between MPV, PDW and DTS.
Rasim Kutlu, Mehmet Erdem Memetoğlu, Tolkun Muratalievic Murataliev, Kadir Gökhan Saçkan, Hasan Yaşar Relationship between Duke Treadmill Score and platelet volume indices in predicting coronary artery disease // Russian Open Medical Journal, Vol. 4, Issue 4, 2015, pp. 0-0

In accordance with the concepts of autonomic heart control system functioning listed above, it provoked an direct interest, in particular, to studying of a dynamic of 0,1 Hz oscillations of the HRV in subjects with different EF of the left ventricle. The aim of the present study was investigation of dynamic stability of 0,1 Hz component of the HRV spectrum in patients with coronary artery disease (CAD) and different EF during veloergometric tests under controlled breathing with 10 seconds period. Methods: 45 male patients with CAD aged of 50±3 years with left ventricle EF<50% and 35 male patients with CAD aged of 52±6 years with left ventricle EF>60% were involved in the study. Veloergometric test was performed. Registration of R-R intervals was performed in relaxed probationer’s condition (sedentary posture) and in 90 seconds after the beginning of 25 Wt load stage of veloergometric test. The duration of R-R chain registration was 5 minutes. Frequency assessments of HRV obtained with the help of R-R chain spectrum construction on the basis of autoregressive model. Results: In process of studying of 0,1 Hz component of the HRV spectrum absence of any reliable differences in its spectral power in patients with normal and damaged EF was shown (Table 1 [Tab. 1]). Under the load rising till 25 Wt in subjects with EF<50% consequent depression of 0,1 Hz component spectral power in 2-3 times in comparison with the relaxed condition was observed (table). At the same time, there was no similar reliable expressed dynamic in the group with EF>60%. It possible to say that the activity level of the 0,1 Hz oscillations in the autonomic heart control system in subjects with EF>60% is characterized by relative tolerance to low-intensive loads, while in patients with EF<50% the activity of 0,1 Hz oscillations is very unstable to the same loads. Conclusions: The stability of 0,1 Hz component of the HRV spectrum to low intensity loads associates with the severity of myocardial contractility damage. The power dynamic of 0,1 Hz component of the HRV spectrum may be considered an independent index of dynamic stability of the heart autonomic control.
Abstract book of 33rd International Congress on Electrocardiology, Cologne, Germany, June 28th - July 1st, 2006; PS88: p 36

Phase locking of 0.1 Hz oscillations in heart rhythm and filling the vessels of microcirculation is a characteristic of autonomic control responsible for synchronization of cardiovascular system parts such as heart and vessels of microcirculation. Purpose: To study the impact of methoprolol tartrate (“Metocard”, Polpharma) intake on the dynamic of cardiovascular system parts synchronization in patients with coronary artery disease (CAD) who have had myocardial infarction (MI). Methods: 43 patients (24 men and 19 women) aged 63±8 who had MI 6 month ago were involved in the study. Synchronous 10 minutes record of electrocardiogram (ECG) and pulsogram during orthostatic test was performed. The first (initial) record was carried out in 6 month after MI, the second one – after 3 month of methoprolol intake (200 mg per day). The total duration of all lengths of 0,1 Hz rhythms phase locking in RR-chain and in pulsogram was estimated. This index expressed in percents from total record duration was called summary percent of synchronization (Sps, %). Results: All of probationers were divided into two groups according to orthostatic Sps dynamic. 21 probationers who have shown the positive Sps dynamic under methoprolol intake were related to the group A, 16 probationers who have shown the negative Sps dynamic under methoprolol intake were related to the group B (see Table 1 [Tab. 1]; Me (25%; 75%)). Conclusion: Methoprolol intake were associated with the negative orthostatic Sps dynamic in 37,2% of probationers. We considered this phenomenon showing the worsening of adaptative reserve of cardiovascular system parts autonomic control. It is necessary to assess individual dynamic of adaptative reserve of autonomic control under methoprolol intake in CAD patients who have had MI.
Abstract book of 33rd International Congress on Electrocardiology, Cologne, Germany, June 28th - July 1st, 2006; VO4: p 3-4 // Journal of Electrocardiology. - 2007. - Vol. 40. - Iss. 1, Suppl. - P. S74.