Purpose — Studying of kliniko-morphological features of a pathology of a gullet, stomach, duodenal gut and role of indicators apoptosis and proliferation in pathology development esofagogastroduodenal zones at alcoholic liver disease. 42 patients with an alcoholic hepatitis and 44 patients a cirrhosis are surveyed. By all it is spent endoscopic, histo-logic and immuno-histochemical inspection. By means of sets of antibodies studied proliferation activity epitheliocytes of stomach At patients at transformation of a chronic alcoholic hepatitis in a cirrhosis accrue atrophy changes of a mucous membrane of a stomach, against against which chronic erosion or peptic ulcers without inflammations are marked. Processes proliferation and apoptosis are activated, that to the full defines morphological changes gastroduodenal zones Strengthening of processes proliferation and apoptosis promotes progressing of structural changes esophagogas-tricduodenal zones that can serve additional diagnostic and prognostic as criterion.
Sushchenko M.A., Kozlova I.V. Klinico-diagnostic value of indicators apoptosis and proliferation esofagogastroduode-nal zones at alcoholic liver disease // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 347-352

The examination of morphofunctional features of esophagus, stomach, and duodenum as well as the role of diffusive endocrine system's cells in development of esophagogastroduodenal zone in patients without gallbladder is the purpose of the study. 80 patients with various periods after cholecystectomy and 72 patients with cholelithiasis were examined. Endo-scopic, histological and immuno-histochemical studies were carried out against all examined patients. The amount of epitheliocytes producing motilin (EC2), glucagon (L), and pancreatic polypeptide (PP) in duodenum were determined using antibodies sets. Esophagitis, atrophic- and reflux-gastritis, duodenal reflux are positively rather frequently met, atrophy and dysplasia of gastric mucous membrane increase in patients without gallbladder during the time after cholecystectomy. Hypoplasia of epithelial cells producing motilin, glucagon and pancreatic polipetide progresses. The development of duodenal and gastroesophagial reflux is associated with hypoplasia of epithelicytes producing motilin; the development of erosive changes is connected with hypoplasia of L and PP cells; the development of atrophic changes is closely related with hypoplasia of all studied cell types. The decrease of hormone producing epythelicytes promotes initiation and persistence of morphofunctional changes in esophagogastricduodenal zone. And this in turn can serve as additional diagnostic and prognostic criterion.
Graushkina E.V., Kozlova I.V., Fedorov V.E. Morphometric analysis of diffuse endocrine system's components in esoph-agogastroduodenal zone in different periods after cholecystectomy // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 342-347