Goal: to examine the effectiveness of use low coherent reflectometry method for diagnostic purposes in clinical dermatology. Materials and methods. For measurements optical coherence tomography OCS1300SS (Thorlab, USA) with swiped frequency was used. 12 patients with different skin diseases were studied (psoriasis, acne, scleroderma, etc.). Results. Distinct border was detected between layers with different optical characteristics (and structure) at a depth of 1000 m to 2000 microns for majority of the samples studied. It is important to note that a good regerneration of distribution of the interference signal during transmission from one section to another and close to an exponential decay of signal with an increase in depth of probing. Conclusion. As a criterion of pathological changes,may be proposed the degree of spatial uniformity in distribution decay constant of interference signal in depth obtained with help of low coherent reflectometry (in vivo).
Zimnyakov D.A., Utz S.R., Galkina E.M., Yuvchenko S.A., Alonova I.V., Artemina E.M., Ushakova O.V. Low coherence re-flectometry of skin: benefits for skin imaging // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 376-380