This Investigation is devoted to the search for new effective anticancer drugs, which is one of the priority areas of medicine. Effect of extracts of maize anthocyanin and Gratiola officinalis drug was studied by using morphological and biochemical methods in experiments in vivo on 30 laboratory rats with transplanted liver cancer PC-1. It was found that an extract of Gratiola officinalis has selective cytotoxic and cytostatic effects on tumor cells. Zea mays extract reduces endogenous intoxication, but its effect on the tumor requires further study.
Nikita A. Navolokin, Natalya V. Polukonova, Galina N. Maslyakova, Alla B. Bucharskaya, Natalya A. Durnova Effect of extracts of Gratiola officinalis and Zea mays on the tumor and the morphology of the internal organs of rats with transplanted liver cancer // Russian Open Medical Journal, Vol. 1, Issue 2, 2012, pp. 203-0

The purpose of the work is to study antitumor activity of flavonoid-containing extracts of anthocyan maize and gratiola in experiments in vivo and to estimate their effects on the internal organs, tumors and blood of rats with transplanted liver cancer PC-1. Materials and methods: Effect of extracts of anthocyan maize and gratiola has been studied in experiments in vivo in 30 laboratory rats with transplanted liver cancer PC-1 using morphological and biochemical methods. Results: It has been found that extract of gratiola received by a certain way has selective cytotoxic effect on tumor cells. Anthocyan maize extract reduces endogenous intoxication. Conclusion: These results open the prospect of further study of the extract of gratiola in various experimental models of cancer and anthocyan maize extract use may be developed as a means of endogenous intoxication reducing for application in the treatment of cancer. Investigation of anthocyan maize extract may assist in the development of drugs that reduce the endogenous intoxication at the treatment of cancer.
Navolokin N.A., Polukonova N.V., Maslyakova G.N., Bucharskaya А.В., Durnova N.A. Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.) // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 2, 2013, pp. 213-220