The aim of the article is to determine the importance of an integrative approach to identify and analyze the phases or stages of the example of chronic sclerotic disease (CSD). The proposed concept of CSD is to use the diagnostic methods before sclerotic period, based on an analysis of indicators of intensity of the functional systems responsible for collagen formation and collagen lysis taking into account the potential of genetically caused features of sclerosis. Thus, special attention is paid to pre-disease stage including the history and molecular genetic studies which predict the nature of the possible diseases and determine the risk of formation of CSD. The proposed methodology and techniques, as well as obtained with their help data define the possibility of risk groups identification, the direction and volume of the survey.
Kats Ya.A., Parkhoniuk E.V., Skriptsova S.A. Sclerotic disease, integrative diagnosis, chronic forms and treatment of diseases // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 268-274

Current data related to transport of fluid through the covering tissue formations (skin, nail plate, dental enamel, gum valley) are being analyzed. A supposition is made of transtegumental fluid transport (TFT) as a general biological regularity which is specifically manifested in tissues of different functional purposes. Depending on the peculiarity of the organ, the tooth performs the TFT providing functional resistance of the enamel, whose level is clinically detected in the «test of enamel resistance» (TER) used in modern research. The article draws attention to the reasonability of an in-depth study of the tooth physiology, where the central element is TFT. This phenomenon is of interest both from fundamental and highly practical standpoints. Identification of seasonal periods in the functional resistance decline makes it possible to get a distinct effect by means of concentrating prevention efforts on this. The TER sample, as well as other transtegumental fluid transport patterns, is to find place in the system of personalized predictive approach to caries diseases
Okushko V.R. Okushko R.V. Ursan R.V. Functional resistance of enamel and the phenomenon of transtegumental fluid transport // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 211-216