In cases of acute respiratory viral infections (ARI) increased concentration of proinflammatory cytokines IL-8, IL-1β, TNF α and anti-inflammatory cytokines il-10, Il-4 and IL-1RA. With genetic anomalies in genes Toll-4 (Asp 299 Gly) and Toll-6 (Ser 249 Pro) receptors synthesis of anti-inflammatory ...
In cases of acute respiratory viral infections (ARI) increased concentration of proinflammatory cytokines IL-8, IL-1β, TNF α and anti-inflammatory cytokines il-10, Il-4 and IL-1RA. With genetic anomalies in genes Toll-4 (Asp 299 Gly) and Toll-6 (Ser 249 Pro) receptors synthesis of anti-inflammatory cytokines is reduced in carriers of heterozygous variants Asp / Glyv gene Toll-4 receptor, while mutations in the gene for Toll-6 it is reduced in heterozygotes Ser / Pro homozygotes and Pro / Propo compared to patients with SARS children without abnormal disturbances in the signaling receptors.
Л.П. Малежик, М.С. Малежик, Д.Ц. Нимаева, Цырендоржиева В.Б. Наследственные основы низкой противоинфекционной защиты у часто болеющих детей // Бюллетень медицинских Интернет-конференций, Vol. 5, Issue 5, 2016, pp. 757-759
