The effects of gold nanorods to internal organs and liver tumors were studied in rats with combined pathology - alloxan diabetes and transplanted liver tumors at single intravenous administration. The evaluation of morphological and functional changes and gold biodistribution in the internal organs and transplanted liver tumor were conducted. It was found that single intravenous injection of gold nanorods did not cause significant morphological changes in the inner organs and tumor. There was a significant accumulation of gold in the liver and spleen in animals in all experimental groups.
Natalya I. Dikht, Alla B. Bucharskaya, Georgy S. Terentyuk, Galina N. Maslyakova, Olga V. Matveeva, Nikita A. Navolokin, Nikolai G. Khlebtsov, Boris N. Khlebtsov Morphological study of the internal organs in rats with alloxan diabetes and transplanted liver tumor after intravenous injection of gold nanorods // Russian Open Medical Journal, Vol. 3, Issue 3, 2014, pp. 301-0