This article establishes the controllability to the trajectories of a reaction-diffusion-advection system describing predator–prey model by using distributed controls acting on a single equation with the no-flux boundary conditions. We first prove the exact null controllability of an associated linearized problem by establishing an observability estimate, derived from a global Carleman type inequality, for the adjoint system. The proof of the nonlinear problem relies on the suitable regularity of the control and Kakutani’s fixed point theorem.