The aim of the work is to develop an algorithm of differentiated therapy in children with PNE. 234 children aged 5-15 years were studied. Results of treatment of children with primary nocturnal enuresis using the traditional therapeutic scheme and the algorithm of differential therapy based on identification of individual pathology were analyzed. The best clinical effect (recovery— in 73,1%, improvement— in 19,4% of cases) was obtained in children undergone the complex of recommended measures: psychological consultation, rational and family psychotherapy, medication correction, physical and physiotherapy, alarm-monitoring; the complex was used differentially, i.e. depending on the identified pathology. In conclusion the article stated that individual treatment program with the obligatory inclusion of alarm-control for child with PNE should be selected after performing the recommended set of diagnostic measures
Nesterenko O.V., Goremykin V.I., Koroleva I.V., Elizarova S.U., Sidorovich O.V. Differential approach to treatment of primary nocturnal enuresis in children // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 666-670

The analysis of psycho-autonomic status, urodynamics of lower urinary tract, the character of family education in children with various courses of primary night enuresis (PNE) was made. 198 children with PNE and 36 healthy children who formed the control group were examined. It was found out that children with PNE were observed to have detrusion-sphincter dissynergy and inadequate family education; the severity of enuresis correlated with the severity of minimal brain dysfunctions. Peculiarities of autonomic regulation in children with primary nocturnal enuresis were caused by stable increase of the parasympathetic nervous system tonus and decrease of the sympathetic nervous system tonus, the severity of the both increasing with the increase of the disease severity
Nesterenko O.V., Koroleva I.V., Goremykin V.I., Elisarova S.U., Khignyak A.M, Protopopov A.A. Psycho-autonomic and urodynamic disorders in children with primary nocturnal enuresis // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 653-658