60 women were examined with the diagnosis of chronic cystitis in exacerbation period. Cystoscopy with biopsy of urinary bladder mucous was made on the first day and the tenth day. The patients were examined by means of the battery of psychometric and psychological methods. Women were divided into two equal groups. The first group took Furamag, the second group - Furamag and Adaptol. The patients complained of dysuria on the first day There was moderate leukocyturia in the urinalysis. Intensive leukocytic infiltration was determined in the biopsy of urinary bladder mucous. In assessing psychic status in patients, the tendency to social isolation was determined in both groups for the first day Laboratory findings were normalized on the tenth day; the dysuria was cropped in both groups in 100 %. Leukocytic infiltration in the biopsy of urinary bladder mucous was changed by lymphocytic one, and proliferative processes were increased. In the second group of patients more rapid relief of anxiety and depressive disorders was noted
Kurnosova N.V., Kuzmenko A.V., Kuzmenko V.V. Actual aspects of chronic cystitis pharmacotherapy in women in exacerbation period // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 705-708

The analysis of mucosa's state of the bladder in treating the exacerbation chronicle cystitis in 67 women was made. The analysis was made with the use of the method of optical coherent tomography (ОСТ). Dynamic ОСТ was performed in 23 patients after antibacterial treat (after 2 weeks) and in the period of remission. It was 59 ОСТ examinations. After antibacterial treatment the pathologically unchanged mucosa was found in the form of thickening in interu-retericfold in Lieutands triangle, in the neck of urinary bladder. Sub mucosal layer was also think, the structure of fibers was destroyed. Both leucocytic and lymphocytic infiltration in the wall of the bladder was observed. The tissue which reflected the light signal was found in muscle structure in the period of remission. This correspond to fibrosis in the wall of the bladder. In the long process the atrophy of mucosa was found. Thus, pathogenetic therapy should proceed after decrease in expressiveness of clinical displays of disease
O.S. Streltsova, V.N. Krupin, E.V. Zagaynova, E.A. Tararova, V.V. Klochay, E.B. Kiseleva Pathogenetic Aspects of Treatment of a Chronic Cystitis // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 3, 2009, pp. 424-428